Functional Characterization of Stem Cell Activity in the Mouse Mammary Gland

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2010 Sep 21

PMID 20853073

Citations 12

Authors

Robert D Bruno

Gilbert H Smith

Affiliations

Soon will be listed here.

Abstract

Any portion of the mouse mammary gland is capable of recapitulating a clonally derived complete and functional mammary tree upon transplantation into an epithelial divested mammary fat-pad of a recipient host. As such, it is an ideal model tissue for the study somatic stem cell function. This review will outline what is known regarding the function of stem/progenitor cells in the mouse mammary gland, including how progenitor populations can be functionally defined, the evidence for and potential role of selective DNA strand segregation, and the role of the niche in maintaining and controlling stem cell function.

Citing Articles

A 3D bioprinter platform for mechanistic analysis of tumoroids and chimeric mammary organoids.

Reid J, Palmer X, Mollica P, Northam N, Sachs P, Bruno R Sci Rep. 2019; 9(1):7466.

PMID: 31097753 PMC: 6522494. DOI: 10.1038/s41598-019-43922-z.

Tissue specific microenvironments: a key tool for tissue engineering and regenerative medicine.

Sachs P, Mollica P, Bruno R J Biol Eng. 2017; 11:34.

PMID: 29177006 PMC: 5688702. DOI: 10.1186/s13036-017-0077-0.

Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo.

Bruno R, Fleming J, George A, Boulanger C, Schedin P, Smith G Sci Rep. 2017; 7:40196.

PMID: 28071703 PMC: 5223207. DOI: 10.1038/srep40196.

Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis.

George A, Smith G Int J Stem Cell Res Ther. 2016; 3(1).

PMID: 27453956 PMC: 4957014. DOI: 10.23937/2469-570x/1410018.

The dynamics of murine mammary stem/progenitor cells.

Dong Q, Sun L Front Biol (Beijing). 2015; 9(3):175-185.

PMID: 25580105 PMC: 4286328. DOI: 10.1007/s11515-014-1308-0.

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