Mammary Stem Cell Research in Veterinary Science: an Update

Overview

Journal Stem Cells Dev

Date 2013 Jan 31

PMID 23360296

Citations 12

Authors

Bizunesh M Borena

Leen Bussche

Christian Burvenich

Luc Duchateau

Gerlinde R Van de Walle

Affiliations

Soon will be listed here.

Abstract

The mammary gland is an organ with a remarkable regenerative capacity that can undergo multiple cycles of proliferation, lactation, and involution. Growing evidence suggests that these changes are driven by the coordinated division and differentiation of mammary stem cell populations (MaSC). Whereas information regarding MaSC and their role in comparative mammary gland physiology is readily available in human and mice, such information remains scarce in most veterinary mammal species such as cows, horses, sheep, goats, pigs, and dogs. We believe that a better knowledge on the MaSC in these species will not only help to gain more insights into mammary gland (patho) physiology in veterinary medicine, but will also be of value for human medicine. Therefore, this review summarizes the current knowledge on stem cell isolation and characterization in different mammals of veterinary importance.

Citing Articles

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Exploring cell surface markers and cell-cell interactions of human breast milk stem cells.

Coni P, Piras M, Piludu M, Lachowicz J, Matteddu A, Coni S J Public Health Res. 2023; 12(1):22799036221150332.

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Asymmetric cell division of mammary stem cells.

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Development and Pathology of the Equine Mammary Gland.

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Beyond tradition and convention: benefits of non-traditional model organisms in cancer research.

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References

Penzo C, ROSS M, Muirhead R, Else R, Argyle D . Effect of recombinant feline interferon-omega alone and in combination with chemotherapeutic agents on putative tumour-initiating cells and daughter cells derived from canine and feline mammary tumours. Vet Comp Oncol. 2009; 7(4):222-9. DOI: 10.1111/j.1476-5829.2009.00192.x. View

Martignani E, Eirew P, Eaves C, Baratta M . Functional identification of bovine mammary epithelial stem/progenitor cells. Vet Res Commun. 2009; 33 Suppl 1:101-3. DOI: 10.1007/s11259-009-9254-z. View

Seaberg R, van der Kooy D . Stem and progenitor cells: the premature desertion of rigorous definitions. Trends Neurosci. 2003; 26(3):125-31. DOI: 10.1016/S0166-2236(03)00031-6. View

Rauner G, Barash I . Cell hierarchy and lineage commitment in the bovine mammary gland. PLoS One. 2012; 7(1):e30113. PMC: 3258259. DOI: 10.1371/journal.pone.0030113. View

Woodward W, Chen M, Behbod F, Rosen J . On mammary stem cells. J Cell Sci. 2005; 118(Pt 16):3585-94. DOI: 10.1242/jcs.02532. View

Capuco A, Evock-Clover C, Minuti A, Wood D . In vivo expansion of the mammary stem/ progenitor cell population by xanthosine infusion. Exp Biol Med (Maywood). 2009; 234(4):475-82. DOI: 10.3181/0811-RM-320. View

Holland M, Stasko J, Holland R . Influence of extracellular matrix on bovine mammary gland progenitor cell growth and differentiation. Am J Vet Res. 2007; 68(5):476-82. DOI: 10.2460/ajvr.68.5.476. View

Kumaraguruparan R, Prathiba D, Nagini S . Of humans and canines: Immunohistochemical analysis of PCNA, Bcl-2, p53, cytokeratin and ER in mammary tumours. Res Vet Sci. 2006; 81(2):218-24. DOI: 10.1016/j.rvsc.2005.08.002. View

Takaishi S, Okumura T, Tu S, Wang S, Shibata W, Vigneshwaran R . Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells. 2009; 27(5):1006-20. PMC: 2746367. DOI: 10.1002/stem.30. View

10.

Munson L, Moresco A . Comparative pathology of mammary gland cancers in domestic and wild animals. Breast Dis. 2007; 28:7-21. DOI: 10.3233/bd-2007-28102. View

11.

Parmar H, Cunha G . Epithelial-stromal interactions in the mouse and human mammary gland in vivo. Endocr Relat Cancer. 2004; 11(3):437-58. DOI: 10.1677/erc.1.00659. View

12.

Capuco A . Identification of putative bovine mammary epithelial stem cells by their retention of labeled DNA strands. Exp Biol Med (Maywood). 2007; 232(10):1381-90. DOI: 10.3181/0703-RM-58. View

13.

Jones P, Watt F . Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell. 1993; 73(4):713-24. DOI: 10.1016/0092-8674(93)90251-k. View

14.

Prpar S, Martignani E, Dovc P, Baratta M . Identification of goat mammary stem/progenitor cells. Biol Reprod. 2012; 86(4):117. DOI: 10.1095/biolreprod.111.095489. View

15.

Proia D, Kuperwasser C . Reconstruction of human mammary tissues in a mouse model. Nat Protoc. 2007; 1(1):206-14. DOI: 10.1038/nprot.2006.31. View

16.

Prince J, Klinowska T, Marshman E, Lowe E, Mayer U, Miner J . Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo. Dev Dyn. 2002; 223(4):497-516. DOI: 10.1002/dvdy.10070. View

17.

Young L . Mus tales: a hands-on view. J Mammary Gland Biol Neoplasia. 2008; 13(3):343-9. DOI: 10.1007/s10911-008-9088-2. View

18.

Fan Y, Chong Y, Choolani M, Cregan M, Chan J . Unravelling the mystery of stem/progenitor cells in human breast milk. PLoS One. 2011; 5(12):e14421. PMC: 3010984. DOI: 10.1371/journal.pone.0014421. View

19.

DANIEL C, Young L, Medina D, DeOME K . The influence of mammogenic hormones on serially transplanted mouse mammary gland. Exp Gerontol. 1971; 6(1):95-101. DOI: 10.1016/0531-5565(71)90053-2. View

20.

Polyak K, Hahn W . Roots and stems: stem cells in cancer. Nat Med. 2006; 12(3):296-300. DOI: 10.1038/nm1379. View