Bombesin Derivative Radiolabeled with Technetium-99m As Agent for Tumor Identification

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2010 Sep 21

PMID 20850312

Citations 8

Authors

Andre Luis Branco de Barros

Luciene das Gracas Mota

Carolina de Aguiar Ferreira

Monica Cristina de Oliveira

Alfredo Miranda de Goes

Valbert Nascimento Cardoso

Affiliations

Soon will be listed here.

Abstract

A bombesin derivative was successfully radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Thus, (99m)Tc-HYNIC-Bombesin((7-14)) could be used as an agent for tumor diagnosis.

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