Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2010 Sep 18

PMID 20848167

Citations 42

Authors

Masaaki Okubo

Tomomitsu Tahara

Tomoyuki Shibata

Hiromi Yamashita

Masakatsu Nakamura

Daisuke Yoshioka

Joh Yonemura

Yoshio Kamiya

Takamitsu Ishizuka

Yoshihito Nakagawa

Mitsuo Nagasaka

Masami Iwata

Hideto Yamada

Ichiro Hirata

Tomiyasu Arisawa

Affiliations

Soon will be listed here.

Abstract

Background: Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human diseases. We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.

Methods: The rs11614913 (T > C), rs2910164 (C > G), and rs3746444 (A > G) SNPs were genotyped in 170 UC and 403 control subjects.

Results: The rs3746444 AG genotype was significantly higher among the UC group (odds ratio (OR) = 1.51, 95% CI = 1.03-2.21, p = 0.037). The rs3746444 AG genotype was associated with onset at an older age (OR = 1.70, 95% CI = 1.04-2.78, p = 0.035), left-sided colitis and pancolitis (left-sided colitis, OR = 2.10, 95% CI = 1.12-3.94, p = 0.024; pancolitis, OR = 1.81, 95% CI = 1.09-3.01, p = 0.028, left-sided colitis + pancolitis, OR = 1.91, 95% CI = 1.26-2.92, p = 0.003), higher number of times hospitalized (OR = 2.63, 95% CI = 1.22-5.69, p = 0.017), steroid dependence (OR = 2.63, 95% CI = 1.27-5.44, p = 0.014), and refractory phenotypes (OR = 2.76, 95% CI = 1.46-5.21, p = 0.002) while the rs3746444 AA genotype was inversely associated with the number of times hospitalized (2∼, OR = 0.36, 95% CI = 0.17-0.79, p = 0.012), steroid dependence (OR = 0.42, 95% CI = 0.21-0.88, p = 0.021), and refractory phenotypes (OR = 0.38, 95% CI = 0.20-0.72, p = 0.003). The rs1161913 TT genotype also held a significantly higher risk of refractory phenotype (T/T vs. T/C + C/C, OR = 2.21, 95% CI = 1.17-4.18, p = 0.016).

Conclusions: Our results provided the first evidence that rs3746444 SNP may influence the susceptibility to UC, and both rs3746444 and rs11614913 SNPs may influence the pathophysiological features of UC.

Citing Articles

MiR-146a (rs2910164) Gene Polymorphism and Its Impact on Circulating MiR-146a Levels in Patients with Inflammatory Bowel Diseases.

Ghorab R, Fouad S, Sherief A, El-Sehsah E, Shamloul S, Taha S Inflammation. 2024; .

PMID: 39103590 DOI: 10.1007/s10753-024-02108-0.

Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis.

Kong X, Diao S, Xu H, Sun J, Ma B PLoS One. 2022; 17(3):e0266265.

PMID: 35358276 PMC: 8970500. DOI: 10.1371/journal.pone.0266265.

SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes.

Chhichholiya Y, Suryan A, Suman P, Munshi A, Singh S Front Genet. 2021; 12:793523.

PMID: 34925466 PMC: 8673831. DOI: 10.3389/fgene.2021.793523.

Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease.

Zhang J, Tan H, Cao Q, Su G, Yang P Dis Markers. 2021; 2021:9978460.

PMID: 34659590 PMC: 8519726. DOI: 10.1155/2021/9978460.

Identification of common microRNA between COPD and non-small cell lung cancer through pathway enrichment analysis.

Fathinavid A, Ghobadi M, Najafi A, Masoudi-Nejad A BMC Genom Data. 2021; 22(1):41.

PMID: 34635059 PMC: 8507163. DOI: 10.1186/s12863-021-00986-z.

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