Replication of Signals from Recent Studies of Crohn's Disease Identifies Previously Unknown Disease Loci for Ulcerative Colitis

Overview

Journal Nat Genet

Specialty Genetics

Date 2008 Apr 29

PMID 18438405

Citations 163

Authors

Andre Franke

Tobias Balschun

Tom H Karlsen

Jurgen Hedderich

Sandra May

Tim Lu

Dorthe Schuldt

Susanna Nikolaus

Philip Rosenstiel

Michael Krawczak

Stefan Schreiber

Affiliations

Soon will be listed here.

Abstract

Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.

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