Breast Cancer Heterogeneity: Mechanisms, Proofs, and Implications

Overview

Journal J Cancer

Specialty Oncology

Date 2010 Sep 16

PMID 20842218

Citations 32

Authors

Yi-Hsuan Hsiao

Ming-Chih Chou

Carol Fowler

Jeffrey T Mason

Yan-Gao Man

Affiliations

Soon will be listed here.

Abstract

Human breast cancer represents a group of highly heterogeneous lesions consisting of about 20 morphologically distinct subtypes with substantially different molecular and/or biochemical signatures, clinical courses, and prognoses. This study analyzed the possible correlation between the morphological presentations of breast cancer and two hypothesized models of carcinogenesis, in order to identify the intrinsic mechanism(s) and clinical implications of breast cancer heterogeneity.

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