The Genotoxicity of Particulate and Soluble Chromate in Sperm Whale (physeter Macrocephalus) Skin Fibroblasts

Overview

Journal Environ Mol Mutagen

Specialties Environmental Health
Molecular Biology

Date 2010 Sep 15

PMID 20839228

Citations 11

Authors

John Pierce Wise Sr

Sandra S Wise

Carolyne Lacerte

John Pierce Wise Jr

AbouEl-Makarim Aboueissa

Affiliations

Soon will be listed here.

Abstract

Hexavalent chromium is a marine pollutant of concern, both for the health of ocean ecosystems and for public health. Hexavalent chromium is known to induce genotoxicity in human and other terrestrial mammals. It is also known to be present in both water and air in the marine environment. However, currently there are limited data concerning both chromium levels and its toxicological effects in marine mammals. This study investigated the cytotoxic and genotoxic effects of soluble and particulate hexavalent chromium in sperm whale skin fibroblasts. Both forms of hexavalent chromium induced concentration-dependent increases in cytotoxicity and genotoxicity indicating that these compounds can be a health risk if the whales are exposed to them. These data support a hypothesis that chromium is a concern in the marine environment in general and for the health of sperm whales in particular.

Citing Articles

A whale of a tale: whale cells evade the driving mechanism for hexavalent chromium-induced chromosome instability.

Lu H, Toyoda J, Wise S, Browning C, Speer R, Croom-Perez T Toxicol Sci. 2024; 199(1):49-62.

PMID: 38539048 PMC: 11057468. DOI: 10.1093/toxsci/kfae030.

Parallel evolution of reduced cancer risk and tumor suppressor duplications in .

Vazquez J, Pena M, Muhammad B, Kraft M, Adams L, Lynch V Elife. 2022; 11.

PMID: 36480266 PMC: 9810328. DOI: 10.7554/eLife.82558.

Polycyclic Aromatic Hydrocarbon-DNA Adducts in Gulf of Mexico Sperm Whale Skin Biopsies Collected in 2012.

Poirier M, Marsili L, Fossi M, Godard-Codding C, Hernandez-Ramon E, Si N Toxicol Sci. 2021; 181(1):115-124.

PMID: 33566103 PMC: 8081012. DOI: 10.1093/toxsci/kfab016.

Metal Levels in Southern Right Whales () from Península Valdés, Argentina.

Martino J, Wise S, Perkins C, Sironi M, Wise Sr J J Environ Anal Toxicol. 2019; 3(6).

PMID: 31497377 PMC: 6730668. DOI: 10.4172/2161-0525.1000190.

Intestinal polycyclic aromatic hydrocarbon-DNA adducts in a population of beluga whales with high levels of gastrointestinal cancers.

Poirier M, Lair S, Michaud R, Hernandez-Ramon E, Divi K, Dwyer J Environ Mol Mutagen. 2018; 60(1):29-41.

PMID: 30307653 PMC: 6320268. DOI: 10.1002/em.22251.

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