Topsentinols, 24-isopropyl Steroids from the Marine Sponge Topsentia Sp

Overview

Journal J Nat Prod

Date 2010 Sep 3

PMID 20806907

Citations 10

Authors

Jingqiu Dai

Analia Sorribas

Wesley Y Yoshida

Michelle Kelly

Philip G Williams

Affiliations

Soon will be listed here.

Abstract

Three isopropyl steroids, topsentinols K, L, and K trisulfate (1-3), were isolated from an undescribed species of Topsentia. The structures of the new compounds were determined by extensive 1D and 2D NMR experiments and mass spectrometry measurements. Topsentinol K trisulfate (3) inhibited the aspartic protease BACE1, although in a detergent-dependent manner suggestive of nonspecific aggregation.

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