Leucine-rich Repeat Protein PRAME: Expression, Potential Functions and Clinical Implications for Leukaemia

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2010 Aug 31

PMID 20799951

Citations 46

Authors

Frances Wadelin

Joel Fulton

Paul A McEwan

Keith A Spriggs

Jonas Emsley

David M Heery

Affiliations

Soon will be listed here.

Abstract

PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.

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References

Nakamura Y, Tanaka F, Nagahara H, Ieta K, Haraguchi N, Mimori K . Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer. Ann Surg Oncol. 2006; 14(2):885-92. DOI: 10.1245/s10434-006-9121-x. View

Evsikov A, Graber J, Brockman J, Hampl A, Holbrook A, Singh P . Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Genes Dev. 2006; 20(19):2713-27. PMC: 1578697. DOI: 10.1101/gad.1471006. View

Griffioen M, Kessler J, Borghi M, van Soest R, van der Minne C, Nouta J . Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy. Clin Cancer Res. 2006; 12(10):3130-6. DOI: 10.1158/1078-0432.CCR-05-2578. View

Roman-Gomez J, Jimenez-Velasco A, Agirre X, Castillejo J, Navarro G, Jose-Eneriz E . Epigenetic regulation of PRAME gene in chronic myeloid leukemia. Leuk Res. 2007; 31(11):1521-8. DOI: 10.1016/j.leukres.2007.02.016. View

Oberthuer A, Hero B, Spitz R, Berthold F, Fischer M . The tumor-associated antigen PRAME is universally expressed in high-stage neuroblastoma and associated with poor outcome. Clin Cancer Res. 2004; 10(13):4307-13. DOI: 10.1158/1078-0432.CCR-03-0813. View

Lee M, Kim Y . Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem. 2007; 76:447-80. DOI: 10.1146/annurev.biochem.76.060605.122847. View

Greiner J, Schmitt M, Li L, Giannopoulos K, Bosch K, Schmitt A . Expression of tumor-associated antigens in acute myeloid leukemia: Implications for specific immunotherapeutic approaches. Blood. 2006; 108(13):4109-17. DOI: 10.1182/blood-2006-01-023127. View

Birtle Z, Goodstadt L, Ponting C . Duplication and positive selection among hominin-specific PRAME genes. BMC Genomics. 2005; 6:120. PMC: 1262708. DOI: 10.1186/1471-2164-6-120. View

Tajeddine N, Millard I, Gailly P, Gala J . Real-time RT-PCR quantification of PRAME gene expression for monitoring minimal residual disease in acute myeloblastic leukaemia. Clin Chem Lab Med. 2006; 44(5):548-55. DOI: 10.1515/CCLM.2006.106. View

10.

Heery D, Hoare S, Hussain S, Parker M, SHEPPARD H . Core LXXLL motif sequences in CREB-binding protein, SRC1, and RIP140 define affinity and selectivity for steroid and retinoid receptors. J Biol Chem. 2000; 276(9):6695-702. DOI: 10.1074/jbc.M009404200. View

11.

Kelley L, Sternberg M . Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc. 2009; 4(3):363-71. DOI: 10.1038/nprot.2009.2. View

12.

Qin Y, Zhu H, Jiang B, Li J, Lu X, Li L . Expression patterns of WT1 and PRAME in acute myeloid leukemia patients and their usefulness for monitoring minimal residual disease. Leuk Res. 2008; 33(3):384-90. DOI: 10.1016/j.leukres.2008.08.026. View

13.

Rezvani K, Yong A, Tawab A, Jafarpour B, Eniafe R, Mielke S . Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia. Blood. 2008; 113(10):2245-55. PMC: 2652370. DOI: 10.1182/blood-2008-03-144071. View

14.

Epping M, Wang L, Plumb J, Lieb M, Gronemeyer H, Brown R . A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors. Proc Natl Acad Sci U S A. 2007; 104(45):17777-82. PMC: 2077016. DOI: 10.1073/pnas.0702518104. View

15.

Proto-Siqueira R, Figueiredo-Pontes L, Panepucci R, Garcia A, Rizzatti E, Nascimento F . PRAME is a membrane and cytoplasmic protein aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma. Leuk Res. 2006; 30(11):1333-9. DOI: 10.1016/j.leukres.2006.02.031. View

16.

McEwan P, Scott P, Bishop P, Bella J . Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans. J Struct Biol. 2006; 155(2):294-305. DOI: 10.1016/j.jsb.2006.01.016. View

17.

Sun Y, Urquidi V, Goodison S . Derivation of molecular signatures for breast cancer recurrence prediction using a two-way validation approach. Breast Cancer Res Treat. 2009; 119(3):593-9. PMC: 2844120. DOI: 10.1007/s10549-009-0365-6. View

18.

Williams J, Chen G, Zhu L, Rest R . Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. Mol Microbiol. 1998; 27(1):171-86. DOI: 10.1046/j.1365-2958.1998.00670.x. View

19.

Croce C, Huebner K, Isobe M, Fainstain E, Lifshitz B, Shtivelman E . Mapping of four distinct BCR-related loci to chromosome region 22q11: order of BCR loci relative to chronic myelogenous leukemia and acute lymphoblastic leukemia breakpoints. Proc Natl Acad Sci U S A. 1987; 84(20):7174-8. PMC: 299252. DOI: 10.1073/pnas.84.20.7174. View

20.

Oehler V, Guthrie K, Cummings C, Sabo K, Wood B, Gooley T . The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells. Blood. 2009; 114(15):3299-308. PMC: 2759652. DOI: 10.1182/blood-2008-07-170282. View