Full-length Genome Sequence of a Simian Immunodeficiency Virus (SIV) Infecting a Captive Agile Mangabey (Cercocebus Agilis) is Closely Related to SIVrcm Infecting Wild Red-capped Mangabeys (Cercocebus Torquatus) in Cameroon

Overview

Journal J Gen Virol

Specialty Microbiology

Date 2010 Aug 28

PMID 20797968

Citations 8

Authors

Steve Ahuka-Mundeke

Florian Liegeois

Ahidjo Ayouba

Yacouba Foupouapouognini

Eric Nerrienet

Eric Delaporte

Martine Peeters

Affiliations

Soon will be listed here.

Abstract

Simian immunodeficiency viruses (SIVs) are lentiviruses that infect an extensive number of wild African primate species. Here we describe for the first time SIV infection in a captive agile mangabey (Cercocebus agilis) from Cameroon. Phylogenetic analysis of the full-length genome sequence of SIVagi-00CM312 showed that this novel virus fell into the SIVrcm lineage and was most closely related to a newly characterized SIVrcm strain (SIVrcm-02CM8081) from a wild-caught red-capped mangabey (Cercocebus torquatus) from Cameroon. In contrast to red-capped mangabeys, no 24&emsp14;bp deletion in CCR5 has been observed in the agile mangabey. Further studies on wild agile mangabeys are needed to determine whether agile and red-capped mangabeys are naturally infected with the same SIV lineage, or whether this agile mangabey became infected with an SIVrcm strain in captivity. However, our study shows that agile mangabeys are susceptible to SIV infection.

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