Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1

Overview

Journal Science

Specialty Science

Date 2006 May 27

PMID 16728595

Citations 366

Authors

Brandon F Keele

Fran Van Heuverswyn

Yingying Li

Elizabeth Bailes

Jun Takehisa

Mario L Santiago

Frederic Bibollet-Ruche

Yalu Chen

Louise V Wain

Florian Liegeois

Severin Loul

Eitel Mpoudi Ngole

Yanga Bienvenue

Eric Delaporte

John F Y Brookfield

Paul M Sharp

George M Shaw

Martine Peeters

Beatrice H Hahn

Affiliations

Soon will be listed here.

Abstract

Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic (group M) and nonpandemic (group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1.

Citing Articles

Phylogenetic evidence of extensive spatial mixing of diverse HIV-1 group M lineages within Cameroon but not between its neighbours.

Godwe C, Goni O, San J, Sonela N, Tchakoute M, Nanfack A Virus Evol. 2024; 10(1):veae070.

PMID: 39386075 PMC: 11463025. DOI: 10.1093/ve/veae070.

Local genetic adaptation to habitat in wild chimpanzees.

Ostridge H, Fontsere C, Lizano E, Soto D, Schmidt J, Saxena V bioRxiv. 2024; .

PMID: 39026872 PMC: 11257515. DOI: 10.1101/2024.07.09.601734.

Expectation-Maximization enables Phylogenetic Dating under a Categorical Rate Model.

Mai U, Charvel E, Mirarab S Syst Biol. 2024; 73(5):823-838.

PMID: 38970346 PMC: 11524793. DOI: 10.1093/sysbio/syae034.

No detectable differences in Nef-mediated downregulation of HLA-I and CD4 molecules among HIV-1 group M lineages circulating in Cameroon, where the pandemic originated.

Sonela N, Mann J, Godwe C, Goni O, Tchakoute M, Nkoue N Front Virol. 2024; 4.

PMID: 38883214 PMC: 7616105. DOI: 10.3389/fviro.2024.1379217.

An ounce of prevention is better : Monitoring wildlife health as a tool for pandemic prevention.

Gogarten J, Dux A, Grassle T, Lumbu C, Markert S, Patrono L EMBO Rep. 2024; 25(7):2819-2831.

PMID: 38849672 PMC: 11239677. DOI: 10.1038/s44319-024-00156-z.

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