Restless Legs Syndrome and Parkinson's Disease in Men

Overview

Journal Mov Disord

Date 2010 Aug 26

PMID 20737545

Citations 15

Authors

Xiang Gao

Michael A Schwarzschild

Eilis J OReilly

Hao Wang

Alberto Ascherio

Affiliations

Soon will be listed here.

Abstract

We examined whether men with restless legs syndrome (RLS) have a higher prevalence of Parkinson's disease (PD) among 23,119 US participants of the Health Professional Follow-up Study who were free of diabetes and arthritis. RLS was assessed using a set of standardized questions recommended by the International RLS Study Group. PD cases were identified by self-reported questionnaires and confirmed by review of medical records. Compared to men without RLS, multivariate-adjusted odds ratios for PD were 1.1 (95% confidence interval: 0.4, 3.0) for men with RLS symptoms 5-14 times per month and 3.09 (95% confidence interval: 1.5, 6.2; P trend = 0.003) for those with symptoms 15 times or more per month, after adjusting for age, smoking, use of antidepressant, and other covariates. In conclusion, men with RLS are more likely to have concurrent PD. Prospective studies are warranted to clarify the temporal relationship between RLS and PD.

Citing Articles

Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease.

Bliwise D, Karroum E, Greer S, Factor S, Trotti L J Parkinsons Dis. 2022; 12(4):1339-1344.

PMID: 35311713 PMC: 9156558. DOI: 10.3233/JPD-213100.

Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease.

Estiar M, Senkevich K, Yu E, Varghaei P, Krohn L, Bandres-Ciga S Mov Disord. 2021; 36(8):1967-1972.

PMID: 33974305 PMC: 9017317. DOI: 10.1002/mds.28640.

Leg restlessness preceding the onset of motor symptoms of Parkinson disease: A case series of 5 patients.

Suzuki K, Fujita H, Watanabe Y, Matsubara T, Kadowaki T, Sakuramoto H Medicine (Baltimore). 2019; 98(33):e16892.

PMID: 31415433 PMC: 6831196. DOI: 10.1097/MD.0000000000016892.

Metabolic syndrome and risk of Parkinson disease: A nationwide cohort study.

Nam G, Kim S, Han K, Kim N, Chung H, Kim J PLoS Med. 2018; 15(8):e1002640.

PMID: 30130376 PMC: 6103502. DOI: 10.1371/journal.pmed.1002640.

Restless Legs Syndrome and Parkinson Disease: A Causal Relationship Between the Two Disorders?.

Ferini-Strambi L, Carli G, Casoni F, Galbiati A Front Neurol. 2018; 9:551.

PMID: 30087647 PMC: 6066514. DOI: 10.3389/fneur.2018.00551.

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