Thyroid Hormone Can Favorably Remodel the Diabetic Myocardium After Acute Myocardial Infarction

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2010 Aug 24

PMID 20730619

Citations 13

Authors

Christos Kalofoutis

Iordanis Mourouzis

Georgios Galanopoulos

Antonios Dimopoulos

Philippos Perimenis

Danai Spanou

Dennis V Cokkinos

Jaipaul Singh

Constantinos Pantos

Affiliations

Soon will be listed here.

Abstract

It has been previously shown that regulators of physiological growth such as thyroid hormone (TH) can favorably remodel the post ischaemic myocardium. Here, we further explored whether this effect can be preserved in the presence of co-morbidities such as diabetes which accelerates cardiac remodeling and increases mortality after myocardial infarction. Acute myocardial infarction (AMI) was induced by left coronary ligation in rats with type I diabetes (DM) induced by streptozotocin administration (STZ; 35 mg/kg; i.p.) while sham-operated animals served as controls (SHAM). AMI resulted in distinct changes in cardiac function and geometry; EF% was significantly decreased in DM-AMI [37.9 ± 2.0 vs. 74.5 ± 2.1 in DM-SHAM]. Systolic and diastolic chamber dimensions were increased without concomitant increase in wall thickness and thus, wall tension index [WTI, the ratio of (Left Ventricular Internal Diameter at diastole)/2*(Posterior Wall thickness)], an index of wall stress, was found to be significantly increased in DM-AMI; 2.27 ± 0.08 versus 1.70 ± 0.05. 2D-Strain echocardiographic analysis showed reduced systolic radial strain in all segments, indicating increased loss of cardiac myocytes in the infarct related area and less compensatory hypertrophy in the viable segments. This response was accompanied by a marked decrease in the expression of TRα1 and TRβ1 receptors in the diabetic myocardium without changes in circulating T3 and T4. Accordingly, the expression of TH target genes related to cardiac contractility was altered; β-MHC and PKCα were significantly increased. TH (L-T4 and L-T3) administration prevented these changes and resulted in increased EF%, normal wall stress and increased systolic radial strain in all myocardial segments. Acute myocardial infarction in diabetic rats results in TH receptor down-regulation with important physiological consequences. TH treatment prevents this response and improves cardiac hemodynamics.

Citing Articles

A Role of Thyroid Hormones in Acute Myocardial Infarction: An Update.

Rasool R, Unar A, Jafar T, Chanihoon G, Mubeen B Curr Cardiol Rev. 2022; 19(1):e280422204209.

PMID: 35657286 PMC: 10201880. DOI: 10.2174/1573403X18666220428121431.

Selenoprotein DIO2 Is a Regulator of Mitochondrial Function, Morphology and UPRmt in Human Cardiomyocytes.

Bomer N, Pavez-Giani M, Deiman F, Linders A, Hoes M, Baierl C Int J Mol Sci. 2021; 22(21).

PMID: 34769334 PMC: 8584701. DOI: 10.3390/ijms222111906.

Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes.

Benedetti V, Lavecchia A, Locatelli M, Brizi V, Corna D, Todeschini M JCI Insight. 2019; 4(18).

PMID: 31534055 PMC: 6795387. DOI: 10.1172/jci.insight.130249.

Louzada R, Carvalho D Front Endocrinol (Lausanne). 2018; 9:394.

PMID: 30072951 PMC: 6060242. DOI: 10.3389/fendo.2018.00394.

Time‑dependent and independent effects of thyroid hormone administration following myocardial infarction in rats.

Iliopoulou I, Mourouzis I, Lambrou G, Iliopoulou D, Koutsouris D, Pantos C Mol Med Rep. 2018; 18(1):864-876.

PMID: 29767239 PMC: 6059718. DOI: 10.3892/mmr.2018.9008.

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