Protection of the Abnormal Heart

Overview

Journal Heart Fail Rev

Date 2007 May 23

PMID 17516163

Citations 5

Authors

Constantinos Pantos

Iordanis Mourouzis

Dennis V Cokkinos

Affiliations

Soon will be listed here.

Abstract

Myocardial ischemia and reperfusion injury have been extensively investigated in the laboratory mainly in healthy tissues. However, in clinical settings, ischemic heart disease coexists with certain illnesses, which could potentially influence the response of the myocardium to ischemia and reperfusion. Recent research has revealed that the abnormal heart may not be always vulnerable to ischemic injury. Furthermore, the effect of powerful means of protection, such as ischemic preconditioning, may not be in operation under certain pathological conditions. With this evidence in mind, the present review will focus on the response of the abnormal heart to ischemia and reperfusion, the possible underlying mechanisms, and potential cardioprotective strategies.

Citing Articles

Propofol improves recovery of the isolated working hypertrophic heart from ischaemia-reperfusion.

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Effects of ischemic preconditioning on ischemia/reperfusion-induced arrhythmias by upregulatation of connexin 43 expression.

Chen Z, Luo H, Zhuang M, Cai L, Su C, Lei Y J Cardiothorac Surg. 2011; 6:80.

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Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction.

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New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider?.

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Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective.

Gross E, Gross G Drug Discov Today Dis Mech. 2008; 4(3):165-174.

PMID: 18701939 PMC: 2515553. DOI: 10.1016/j.ddmec.2007.10.005.

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