Antihypercholesterolaemic Effect of Ginger Rhizome (Zingiber Officinale) in Rats

Overview

Journal Inflammopharmacology

Specialty Pharmacology

Date 2010 Aug 24

PMID 20730603

Citations 17

Authors

El-Sayed M ElRokh

Nemat A Z Yassin

Siham M A El-Shenawy

Bassant M M Ibrahim

Affiliations

Soon will be listed here.

Abstract

Introduction: Many herbal medicinal products have potential hypocholesterolaemic activity and encouraging safety profiles. However, only a limited amount of clinical research exists to support their efficacy.

Aim Of The Work: The present study was designed to evaluate the antihypercholesterolaemic effects of aqueous ginger (Zingiber officinale) infusion in hypercholesterolaemic rat models.

Methods: 48 rats were used throughout the experiment, which were divided into six groups, eight animals each as follows: normal control group (normal rats which fed with standard diet). After induction of hypercholesterolaemia by feeding rats with high cholesterol diet, the remaining rats were divided into five groups: group 1, hypercholesterolaemic control group (hypercholesterolaemic rats group); groups 2, 3 and 4, rats were given aqueous infusion of ginger (100, 200 and 400 mg/kg, respectively) orally; and group 5, rats were given atorvastatin (0.18 mg/kg) orally as a reference antihypercholesterolaemic drug. The blood was obtained from all groups of rats after being lightly anaesthetized with ether and the following lipid profile [serum total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-C and triglyceride levels] was measured at zero time and 2 and 4 weeks after ginger and atorvastatin treatment, and the risk ratio (TC/HDL-cholesterol) was assessed.

Results: The results revealed that the hypercholesterolaemic rats treated with aqueous ginger infusion in the three doses used after 2 and 4 weeks of treatment induce significant decrease in all lipid profile parameters which were measured and improved the risk ratio.

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References

Reddy A, Lokesh B . Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol Cell Biochem. 1992; 111(1-2):117-24. DOI: 10.1007/BF00229582. View

Tanabe M, Chen Y, Saito K, Kano Y . Cholesterol biosynthesis inhibitory component from Zingiber officinale Roscoe. Chem Pharm Bull (Tokyo). 1993; 41(4):710-3. DOI: 10.1248/cpb.41.710. View

Ney D, Lasekan J, Shinnick F . Soluble oat fiber tends to normalize lipoprotein composition in cholesterol-fed rats. J Nutr. 1988; 118(12):1455-62. DOI: 10.1093/jn/118.12.1455. View

Durrington P . Dyslipidaemia. Lancet. 2003; 362(9385):717-31. DOI: 10.1016/S0140-6736(03)14234-1. View

Soni K, Rajan A, Kuttan R . Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer Lett. 1992; 66(2):115-21. DOI: 10.1016/0304-3835(92)90223-i. View

Wieland H, Seidel D . A simple specific method for precipitation of low density lipoproteins. J Lipid Res. 1983; 24(7):904-9. View

Belinky P, Aviram M, Fuhrman B, Rosenblat M, Vaya J . The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. Atherosclerosis. 1998; 137(1):49-61. DOI: 10.1016/s0021-9150(97)00251-7. View

FRIEDEWALD W, Levy R, Fredrickson D . Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18(6):499-502. View

Cardia G, Grisorio D, Impedovo G, Lillo A, Regina G . Plasma lipids as a risk factor in peripheral vascular disease. Angiology. 1990; 41(1):19-22. DOI: 10.1177/000331979004100103. View

10.

Ness G, Zhao Z, Lopez D . Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation. Arch Biochem Biophys. 1996; 325(2):242-8. DOI: 10.1006/abbi.1996.0030. View

11.

Elam M, Hunninghake D, Davis K, Garg R, JOHNSON C, Egan D . Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial. JAMA. 2000; 284(10):1263-70. DOI: 10.1001/jama.284.10.1263. View

12.

Bhandari U, Kanojia R, Pillai K . Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol. 2005; 97(2):227-30. DOI: 10.1016/j.jep.2004.11.011. View

13.

Srinivasan K, Sambaiah K . The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int J Vitam Nutr Res. 1991; 61(4):364-9. View

14.

Platel K, Srinivasan K . Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung. 2000; 44(1):42-6. DOI: 10.1002/(SICI)1521-3803(20000101)44:1<42::AID-FOOD42>3.0.CO;2-D. View

15.

GOVINDARAJAN V . Ginger--chemistry, technology, and quality evaluation: part 1. Crit Rev Food Sci Nutr. 1982; 17(1):1-96. DOI: 10.1080/10408398209527343. View

16.

Benzie I, Szeto Y . Total antioxidant capacity of teas by the ferric reducing/antioxidant power assay. J Agric Food Chem. 1999; 47(2):633-6. DOI: 10.1021/jf9807768. View

17.

Langner E, Greifenberg S, Gruenwald J . Ginger: history and use. Adv Ther. 1997; 15(1):25-44. View

18.

Liu N, Huo G, Zhang L, Zhang X . [Effect of Zingiber OfficinaleRosc on lipid peroxidation in hyperlipidemia rats]. Wei Sheng Yan Jiu. 2003; 32(1):22-3. View

19.

Sharma R . Effect of hydroxy acids on hypercholesterolaemia in rats. Atherosclerosis. 1980; 37(3):463-8. DOI: 10.1016/0021-9150(80)90152-5. View

20.

Murcia M, Egea I, Romojaro F, Parras P, Jimenez A, Martinez-Tome M . Antioxidant evaluation in dessert spices compared with common food additives. Influence of irradiation procedure. J Agric Food Chem. 2004; 52(7):1872-81. DOI: 10.1021/jf0303114. View