The Antioxidant Activity of Steamed Ginger and Its Protective Effects on Obesity Induced by High-fat Diet in C57BL/6J Mice

Overview

Journal Nutr Res Pract

Specialty Nutritional Sciences

Date 2018 Dec 6

PMID 30515278

Citations 12

Authors

Hee-Jeong Kim

Bohkyung Kim

Eun-Gyung Mun

Soon-Yeon Jeong

Youn-Soo Cha

Affiliations

Soon will be listed here.

Abstract

Background/objectives: Ginger, a root vegetable, is known to have antioxidant and antiobesity effects. Preparation, such as by steaming, can affect the chemical composition of prepared root vegetables or herbs and can change their functional activities. In the present study, we investigated the protective effects of steamed ginger against oxidative stress and steatosis in C57BL/6J mice fed a high-fat diet.

Materials/methods: The levels of polyphenols and flavonoids in two different extracts of steamed ginger, , water extract (SGW) and ethanolic extract (SGE); as well, their antioxidant activities were examined. Forty male C57BL/6J mice were fed a normal diet (ND, n = 10), high-fat diet (HFD, 60% fat, w/w, n = 10), HFD supplemented with 200 mg/kg of SGE or garcinia (GAR) by weight (SGED or GARD, respectively, n = 10) for 12 weeks. Serum chemistry was examined, and the expressions of genes involved in lipid metabolism were determined in the liver. Histological analysis was performed to identify lipid accumulations in epididymal fat pads and liver.

Results: The SGE had higher contents of polyphenols and flavonoids and higher DPPH and ABTS free radical scavenging activities compared to those of SGW. Treatment with SGE or GAR significantly decreased the HFD-induced weight gain. Both SGE and GAR significantly reduced the high serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein levels induced by HFD. Compared to ND, HFD significantly increased hepatic TC and TG levels. SGE or GAR supplementation significantly decreased the increase of hepatic lipids by HFD. Interestingly, SGE had a more significant effect in reducing hepatic TC and TG levels than GAR. Furthermore, hepatic genes involved in lipogenesis and lipolysis were altered in both the SGED and GARD groups.

Conclusions: The present study indicates that steamed ginger supplementation can decrease plasma TC and TG and can inhibit liver steatosis by regulating the expressions of hepatic genes.

Citing Articles

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Anyanwu G, Anzaku D, Bulus Y, Girgi J, Donwell C, Ihuma J J Obes. 2025; 2025:5568216.

PMID: 40026359 PMC: 11870763. DOI: 10.1155/jobe/5568216.

The Effects of Body Fat Reduction through the Metabolic Control of Steam-Processed Ginger Extract in High-Fat-Diet-Fed Mice.

Lee Y, Lee S, Baek H, Kwon J, Baek N, Kang T Int J Mol Sci. 2024; 25(5).

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Bashir K, Kim J, Park H, Lee J, Choi B, Choi J Antioxidants (Basel). 2024; 13(1).

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Insights on Dietary Polyphenols as Agents against Metabolic Disorders: Obesity as a Target Disease.

Aloo S, Ofosu F, Kim N, Kilonzi S, Oh D Antioxidants (Basel). 2023; 12(2).

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The effects of ginger and its constituents in the prevention of metabolic syndrome: A review.

Salaramoli S, Mehri S, Yarmohammadi F, Hashemy S, Hosseinzadeh H Iran J Basic Med Sci. 2022; 25(6):664-674.

PMID: 35949312 PMC: 9320212. DOI: 10.22038/IJBMS.2022.59627.13231.

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