Functionalized Nanopipettes: Toward Label-free, Single Cell Biosensors

Overview

Journal Bioanal Rev

Publisher Springer

Specialty Biology

Date 2010 Aug 24

PMID 20730113

Citations 32

Authors

Paolo Actis

Andy C Mak

Nader Pourmand

Affiliations

Soon will be listed here.

Abstract

Nanopipette technology has been proven to be a label-free biosensor capable of identifying DNA and proteins. The nanopipette can include specific recognition elements for analyte discrimination based on size, shape, and charge density. The fully electrical read-out and the ease and low-cost fabrication are unique features that give this technology an enormous potential. Unlike other biosensing platforms, nanopipettes can be precisely manipulated with submicron accuracy and used to study single cell dynamics. This review is focused on creative applications of nanopipette technology for biosensing. We highlight the potential of this technology with a particular attention to integration of this biosensor with single cell manipulation platforms.

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