Correlation Between Imaging Features and Epithelial Cell Proliferation in Keratocystic Odontogenic Tumour

Overview

Journal Dentomaxillofac Radiol

Publisher Oxford University Press

Date 2010 Aug 24

PMID 20729187

Citations 12

Authors

K Ba

X Li

H Wang

Y Liu

G Zheng

Z Yang

M Li

K Shimizutani

T Koseki

Affiliations

Soon will be listed here.

Abstract

Objectives: this study was undertaken to investigate the relationship between radiographic appearance and epithelial cell proliferations in keratocystic odontogenic tumours (KCOTs).

Methods: a retrospective radiographic analysis was performed on 284 cases of KCOT to gain insight into the radiographic characteristics. Expression of Ki-67 in 30 of the 284 cases was detected by the labelled streptavidin-biotin (LSAB) method and evaluated by an image analysis system.

Results: the radiographic presentation of KCOT was divided into four types: unilocular, multilocular, multiple and naevoid basal cell carcinoma syndrome (NBCCS). The expression of Ki-67 in NBCCS was significantly different from the solitary and multiple KCOTs (P = 0.018, 0.002). In multilocular KCOTs it was also significantly different from the unilocular and syndrome-associated lesions (P = 0.000). In contrast, no significant differences were observed between the solitary and multiple lesions (P = 0.220).

Conclusions: a high correlation exists in KCOT between its biological behaviour and imaging features. The solitary KCOT seems less biologically aggressive and it should be classified as a cyst rather than a tumour. This means that more than half of KCOTs manifest themselves as ordinary cysts.

Citing Articles

Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review.

Almeida L, Loyd D, Boettcher D, Kraft O, Zammuto S Diagnostics (Basel). 2024; 14(12).

PMID: 38928661 PMC: 11202764. DOI: 10.3390/diagnostics14121246.

An Insight Into the Effect of Odontogenic Keratocysts on Surrounding Structures: Cone-Beam Computed Tomography-Based Analysis of Cases.

Ac V, Parihar A, Saxena A Cureus. 2023; 15(6):e40488.

PMID: 37461795 PMC: 10349913. DOI: 10.7759/cureus.40488.

The presentation of odontogenic keratocysts in the jaws with an emphasis on the tooth-bearing area: a systematic review and meta-analysis.

da Silva Y, Stoelinga P, Naclerio-Homem M Oral Maxillofac Surg. 2019; 23(2):133-147.

PMID: 30825057 DOI: 10.1007/s10006-019-00754-5.

Evaluation of keratocystic odontogenic tumors using cone beam computed tomography.

Gumusok M, Toraman Alkurt M, Museyibov F, Ucok O J Istanb Univ Fac Dent. 2017; 50(3):32-37.

PMID: 28955573 PMC: 5573512. DOI: 10.17096/jiufd.58691.

Need to reclassify keratocystic odontogenic tumor into cyst and neoplasm.

Singh H Natl J Maxillofac Surg. 2017; 7(1):111.

PMID: 28163493 PMC: 5242067. DOI: 10.4103/0975-5950.196125.

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