Emerging Roles of the 26S Proteasome in Nuclear Hormone Receptor-regulated Transcription

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2010 Aug 24

PMID 20728592

Citations 7

Authors

Brian R Keppler

Trevor K Archer

H Karimi Kinyamu

Affiliations

Soon will be listed here.

Abstract

The mechanisms by which nuclear hormone receptors (NHRs) regulate transcription are highly dynamic and require interplay between a myriad of regulatory protein complexes including the 26S proteasome. Protein degradation is the most well-established role of the proteasome; however, an increasing body of evidence suggests that the 26S proteasome may regulate transcription in proteolytic and nonproteolytic mechanisms. Here we review how these mechanisms may apply to NHR-mediated transcriptional regulation. This article is part of a Special Issue entitled The 26S Proteasome: When degradation is just not enough!

Citing Articles

Proteasome Inhibition Reprograms Chromatin Landscape in Breast Cancer.

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Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity.

Kinyamu H, Bennett B, Bushel P, Archer T J Biol Chem. 2019; 295(5):1271-1287.

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Hewitt S, Winuthayanon W, Korach K J Mol Endocrinol. 2016; 56(2):R55-71.

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Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.

Chen T, Laurenzana E, Coslo D, Chen F, Omiecinski C Biochem J. 2013; 458(1):95-107.

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