H Karimi Kinyamu
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Explore the profile of H Karimi Kinyamu including associated specialties, affiliations and a list of published articles.
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24
Citations
445
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Recent Articles
1.
Yang J, Kinyamu H, Ward J, Scappini E, Muse G, Archer T
Stem Cells
. 2024 Jun;
42(8):706-719.
PMID: 38825983
The transformation from a fibroblast mesenchymal cell state to an epithelial-like state is critical for induced pluripotent stem cell (iPSC) reprogramming. In this report, we describe studies with PFI-3, a...
2.
Kinyamu H, Bennett B, Ward J, Archer T
Cancer Res Commun
. 2024 Apr;
4(4):1082-1099.
PMID: 38625038
Significance: Our study provides a strong basis for understanding the mechanisms by which proteasome inhibitors exert anticancer effects. We find open chromatin regions that change during proteasome inhibition, are typically...
3.
Kinyamu H, Bennett B, Ward J, Archer T
bioRxiv
. 2023 Oct;
PMID: 37904968
Highlights: Proteasome inhibition uncovers Differential Open Chromatin Regions (DOCRs) in breast cancer cells. Proteasome inhibitor sensitive promoters exhibit a distinctive chromatin architecture with discrete transcription initiation patterns.Proteasome inhibition reprograms accessibility...
4.
Yang J, Kinyamu H, Ward J, Scappini E, Archer T
bioRxiv
. 2023 Oct;
PMID: 37873209
The transformation of fibroblasts into epithelial cells is critical for iPSC reprogramming. In this report, we describe studies with PFI-3, a small molecule inhibitor that specifically targets the bromodomains of...
5.
Shafiee-Kermani F, Carney S, Jima D, Utin U, Farrar L, Oputa M, et al.
Epigenetics
. 2020 Jul;
16(3):289-299.
PMID: 32660355
Studies have suggested that abrogated expression of detoxification enzymes, UGT2B15 and UGT2B17, are associated with prostate tumour risk and progression. We investigated the role of EGF on the expression of...
6.
Kinyamu H, Bennett B, Bushel P, Archer T
J Biol Chem
. 2019 Dec;
295(5):1271-1287.
PMID: 31806706
Proteasome activity is required for diverse cellular processes, including transcriptional and epigenetic regulation. However, inhibiting proteasome activity can lead to an increase in transcriptional output that is correlated with enriched...
7.
OBrien K, Sandler D, Xu Z, Kinyamu H, Taylor J, Weinberg C
Breast Cancer Res
. 2018 Jul;
20(1):70.
PMID: 29996894
Background: Vitamin D has anticarcinogenic and immune-related properties and may protect against some diseases, including breast cancer. Vitamin D affects gene transcription and may influence DNA methylation. Methods: We studied...
8.
Widespread enhancer activation via ERα mediates estrogen response in vivo during uterine development
Jefferson W, Kinyamu H, Wang T, Miranda A, Padilla-Banks E, Suen A, et al.
Nucleic Acids Res
. 2018 Apr;
46(11):5487-5503.
PMID: 29648668
Little is known regarding how steroid hormone exposures impact the epigenetic landscape in a living organism. Here, we took a global approach to understanding how exposure to the estrogenic chemical,...
9.
Singh A, Foley J, Tandon A, Phadke D, Kinyamu H, Archer T
Oncotarget
. 2017 Sep;
8(33):54925-54938.
PMID: 28903392
Lymphatic vasculature is an important part of the cardiovascular system with multiple functions, including regulation of the return of interstitial fluid (lymph) to the bloodstream, immune responses, and fat absorption....
10.
OBrien K, Sandler D, Kinyamu H, Taylor J, Weinberg C
Cancer Epidemiol Biomarkers Prev
. 2017 Aug;
26(12):1761-1771.
PMID: 28830874
We previously observed that high serum 25-hydroxyvitamin D (25(OH)D; >38.0 ng/mL) was inversely associated with breast cancer. Here, we examined effect modification by SNPs in vitamin D-related genes. The Sister...