Determining γδ Versus αß T Cell Development

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2010 Aug 21

PMID 20725107

Citations 77

Authors

Maria Ciofani

Juan Carlos Zuniga-Pflucker

Affiliations

Soon will be listed here.

Abstract

The thymus produces several types of functionally distinct T cell subsets. However, at a more fundamental level only two genetically distinct T cell lineages exist: the γδ and αß T cell lineages. Precisely how these two T cell lineages are generated from common thymocyte progenitor cells remains to be fully elucidated and is under intense investigation. Here, we highlight recent findings that have helped to provide important clues to the mechanisms that underpin the generation of γδ T cells in the mouse thymus.

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