Spatial Organization of Adhesion: Force-dependent Regulation and Function in Tissue Morphogenesis

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2010 Aug 19

PMID 20717145

Citations 59

Authors

Ekaterina Papusheva

Carl-Philipp Heisenberg

Affiliations

Soon will be listed here.

Abstract

Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force-mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis.

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