Attention-deficit/Hyperactivity Disorder in the Context of Autism Spectrum Disorders

Overview

Journal Curr Psychiatry Rep

Publisher Current Science

Specialty Psychiatry

Date 2010 Aug 10

PMID 20694583

Citations 62

Authors

Michael J Murray

Affiliations

Soon will be listed here.

Abstract

Autism spectrum disorders (ASD) are frequently marked by symptoms consistent with attention-deficit/hyperactivity disorder (ADHD), namely inattention, hyperactivity, and impulsivity. Recent work has established that about half of the ASD population also meets diagnostic criteria for ADHD, although the comorbid diagnoses are precluded by the DSM-IV-TR. Individuals with co-occurring ASD and ADHD symptoms are more severely impaired, with significant deficits seen in social processing, adaptive functioning, and executive control. Children with ASD and ADHD symptoms are also prone to motor problems, which lead to especially poor outcomes. Recent work has also demonstrated high rates of ASD symptoms in a subset of children with ADHD. Medication studies have demonstrated the efficacy of methylphenidate, atomoxetine, and guanfacine, among others, in treating ADHD symptoms co-occurring with ASD. However, these effects were not as great as those seen when treating primary ADHD, and they are less well-tolerated in the ASD population.

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References

Dziuk M, Larson J, Apostu A, Mahone E, Denckla M, Mostofsky S . Dyspraxia in autism: association with motor, social, and communicative deficits. Dev Med Child Neurol. 2007; 49(10):734-9. DOI: 10.1111/j.1469-8749.2007.00734.x. View

Posey D, Puntney J, Sasher T, Kem D, McDougle C . Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases. J Child Adolesc Psychopharmacol. 2004; 14(2):233-41. DOI: 10.1089/1044546041649084. View

Pitcher T, Piek J, Hay D . Fine and gross motor ability in males with ADHD. Dev Med Child Neurol. 2003; 45(8):525-35. DOI: 10.1017/s0012162203000975. View

Posey D, Wiegand R, Wilkerson J, Maynard M, Stigler K, McDougle C . Open-label atomoxetine for attention-deficit/ hyperactivity disorder symptoms associated with high-functioning pervasive developmental disorders. J Child Adolesc Psychopharmacol. 2006; 16(5):599-610. DOI: 10.1089/cap.2006.16.599. View

de Boo G, Prins P . Social incompetence in children with ADHD: possible moderators and mediators in social-skills training. Clin Psychol Rev. 2006; 27(1):78-97. DOI: 10.1016/j.cpr.2006.03.006. View

Posey D, Aman M, McCracken J, Scahill L, Tierney E, Eugene Arnold L . Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures. Biol Psychiatry. 2007; 61(4):538-44. DOI: 10.1016/j.biopsych.2006.09.028. View

Goldstein S, Schwebach A . The comorbidity of Pervasive Developmental Disorder and Attention Deficit Hyperactivity Disorder: results of a retrospective chart review. J Autism Dev Disord. 2004; 34(3):329-39. DOI: 10.1023/b:jadd.0000029554.46570.68. View

Nieoullon A . Dopamine and the regulation of cognition and attention. Prog Neurobiol. 2002; 67(1):53-83. DOI: 10.1016/s0301-0082(02)00011-4. View

Gadow K, DeVincent C, Pomeroy J, Azizian A . Psychiatric symptoms in preschool children with PDD and clinic and comparison samples. J Autism Dev Disord. 2004; 34(4):379-93. DOI: 10.1023/b:jadd.0000037415.21458.93. View

10.

Yoo J, Valdovinos M, Williams D . Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature. J Autism Dev Disord. 2007; 37(10):1883-901. DOI: 10.1007/s10803-006-0322-8. View

11.

Stigler K, Desmond L, Posey D, Wiegand R, McDougle C . A naturalistic retrospective analysis of psychostimulants in pervasive developmental disorders. J Child Adolesc Psychopharmacol. 2004; 14(1):49-56. DOI: 10.1089/104454604773840481. View

12.

Pennington B, Ozonoff S . Executive functions and developmental psychopathology. J Child Psychol Psychiatry. 1996; 37(1):51-87. DOI: 10.1111/j.1469-7610.1996.tb01380.x. View

13.

Scahill L, Aman M, McDougle C, McCracken J, Tierney E, Dziura J . A prospective open trial of guanfacine in children with pervasive developmental disorders. J Child Adolesc Psychopharmacol. 2006; 16(5):589-98. DOI: 10.1089/cap.2006.16.589. View

14.

Doyle R, Frazier J, Spencer T, Geller D, Biederman J, Wilens T . Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: a case series. J Atten Disord. 2006; 9(3):543-9. DOI: 10.1177/1087054705284091. View

15.

Smalley S, Loo S, Yang M, Cantor R . Toward localizing genes underlying cerebral asymmetry and mental health. Am J Med Genet B Neuropsychiatr Genet. 2005; 135B(1):79-84. DOI: 10.1002/ajmg.b.30141. View

16.

Corbett B, Constantine L, Hendren R, Rocke D, Ozonoff S . Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Res. 2009; 166(2-3):210-22. PMC: 2683039. DOI: 10.1016/j.psychres.2008.02.005. View

17.

Findling R, McNamara N, Gracious B, ORiordan M, Reed M, Demeter C . Quetiapine in nine youths with autistic disorder. J Child Adolesc Psychopharmacol. 2004; 14(2):287-94. DOI: 10.1089/1044546041649129. View

18.

McCracken J, McGough J, Shah B, Cronin P, Hong D, Aman M . Risperidone in children with autism and serious behavioral problems. N Engl J Med. 2002; 347(5):314-21. DOI: 10.1056/NEJMoa013171. View

19.

Mahone E, Powell S, Loftis C, Goldberg M, Denckla M, Mostofsky S . Motor persistence and inhibition in autism and ADHD. J Int Neuropsychol Soc. 2006; 12(5):622-31. DOI: 10.1017/S1355617706060814. View

20.

Gilger J, Kaplan B . Atypical brain development: a conceptual framework for understanding developmental learning disabilities. Dev Neuropsychol. 2002; 20(2):465-81. DOI: 10.1207/S15326942DN2002_2. View