Homocysteine, Neural Atrophy, and the Effect of Caloric Restriction in Rhesus Monkeys

Overview

Journal Neurobiol Aging

Publisher Elsevier

Specialties Geriatrics
Neurology
Physiology

Date 2010 Aug 10

PMID 20691506

Citations 13

Authors

Auriel A Willette

Catherine Gallagher

Barbara B Bendlin

Donald G McLaren

Erik K Kastman

Elisa Canu

Kris J Kosmatka

Aaron S Field

Andrew L Alexander

Ricki J Colman

Mary-Lou L Voytko

Richard H Weindruch

Christopher L Coe

Sterling C Johnson

Affiliations

Soon will be listed here.

Abstract

Higher serum homocysteine (Hcy) levels in humans are associated with vascular pathology and greater risk for dementia, as well as lower global and regional volumes in frontal lobe and hippocampus. Calorie restriction (CR) in rhesus monkeys (Macaca mulatta) may confer neural protection against age- or Hcy-related vascular pathology. Hcy was collected proximal to a magnetic resonance imaging (MRI) acquisition in aged rhesus monkeys and regressed against volumetric and diffusion tensor imaging indexes using voxel-wise analyses. Higher Hcy was associated with lower white matter volume in pons and corpus callosum. Hcy was correlated with lower gray matter volume and density in prefrontal cortices and striatum. CR did not influence Hcy levels. However, control monkeys exhibited a strong negative correlation between Hcy and global gray matter, whereas no relationship was evident for the CR monkeys. Similar group differences were also seen across modalities in the splenium of the corpus callosum, prefrontal cortices, hippocampus, and somatosensory areas. The data suggest that CR may ameliorate the influence of Hcy on several important age-related parameters of parenchymal health.

Citing Articles

Hypertension With High Homocysteine Is Associated With Default Network Gray Matter Loss.

Kong Y, Li X, Chang L, Liu Y, Jia L, Gao L Front Neurol. 2021; 12:740819.

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Non-human primates as a model for aging.

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Disturbed nitric oxide and homocysteine production are involved in the increased risk of cardiovascular diseases in the F1 offspring of maternal obesity and malnutrition.

Moussa Y, Tawfik S, Haiba M, Saad M, Hanafi M, Abdelkhalek T J Endocrinol Invest. 2016; 40(6):611-620.

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Contributions of Nonhuman Primates to Research on Aging.

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Microstructural white matter tissue characteristics are modulated by homocysteine: a diffusion tensor imaging study.

Hsu J, Chen W, Bai C, Leu J, Hsu C, Viergever M PLoS One. 2015; 10(2):e0116330.

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