Age-related Changes in the Corpus Callosum in Early-onset Bipolar Disorder Assessed Using Volumetric and Cross-sectional Measurements

Overview

Journal Brain Imaging Behav

Publisher Springer

Specialties Neurology
Psychology
Radiology
Social Sciences

Date 2010 Aug 6

PMID 20686873

Citations 7

Authors

Melissa Lopez-Larson

Janis L Breeze

David N Kennedy

Steven M Hodge

Lena Tang

Constance Moore

Anthony J Giuliano

Nikos Makris

Verne S Caviness

Jean A Frazier

Affiliations

Soon will be listed here.

Abstract

Corpus callosum (CC) area abnormalities have been reported in magnetic resonance imaging (MRI) studies of adults and youths with bipolar disorder (BPD), suggesting interhemispheric communication may be abnormal in BPD and may be present early in the course of illness and affect normal neuromaturation of this structure throughout the lifecycle. Neuroimaging scans from 44 youths with DSM-IV BPD and 22 healthy controls (HC) were analyzed using cross-sectional area measurements and a novel method of volumetric parcellation. Univariate analyses of variance were conducted on CC subregions using both volume and traditional area measurements. Youths with BPD had smaller middle and posterior callosal regions, and reduced typical age-related increases in CC size. The cross-sectional area and novel volumetric methodologies resulted in similar findings. Future longitudinal assessments of CC development would track the evolution of callosal abnormalities in youths with BPD and allow exploration of the functional significance of these findings.

Citing Articles

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Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study.

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