Insights into the Phylogeny or Arylamine N-acetyltransferases in Fungi

Overview

Journal J Mol Evol

Specialty Biochemistry

Date 2010 Aug 3

PMID 20676885

Citations 7

Authors

Marta Martins

Julien Dairou

Fernando Rodrigues-Lima

Jean-Marie Dupret

Philippe Silar

Affiliations

Soon will be listed here.

Abstract

Previous studies have shown that Eumycetes fungi can acylate arylamine thanks to arylamine N-acetyltransferases, xenobiotic-metabolizing enzymes also found in animals and bacteria. In this article, we present the results of mining 96 available fungal genome sequences for arylamine N-acetyltransferase genes and propose their phylogeny. The filamentous Pezizomycotina are shown to possess many putative N-acetyltransferases, whilst these are often lacking in other fungal groups. The evolution of the N-acetyltransferases is best explained by the presence of at least one gene in the opisthokont ancestor of the fungi and animal kingdoms, followed by recurrent gene losses and gene duplications. A possible horizontal gene transfer event may have occurred from bacteria to the basidiomycetous yeast Malassezia globosa.

Citing Articles

Biochemical Characterization of Arylamine acetyltransferases From .

Liu X, Liu Y, Zhao G, Zhang Y, Liu L, Wang J Front Microbiol. 2021; 11:595083.

PMID: 33537010 PMC: 7847940. DOI: 10.3389/fmicb.2020.595083.

Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues.

Tsirka T, Konstantopoulou M, Sabbagh A, Crouau-Roy B, Ryan A, Sim E Sci Rep. 2018; 8(1):9759.

PMID: 29950659 PMC: 6021393. DOI: 10.1038/s41598-018-28094-6.

Homologues of xenobiotic metabolizing N-acetyltransferases in plant-associated fungi: Novel functions for an old enzyme family.

Karagianni E, Kontomina E, Davis B, Kotseli B, Tsirka T, Garefalaki V Sci Rep. 2015; 5:12900.

PMID: 26245863 PMC: 4542470. DOI: 10.1038/srep12900.

Biotransformation of Trichoderma spp. and their tolerance to aromatic amines, a major class of pollutants.

Cocaign A, Bui L, Silar P, Chan Ho Tong L, Busi F, Lamouri A Appl Environ Microbiol. 2013; 79(15):4719-26.

PMID: 23728813 PMC: 3719500. DOI: 10.1128/AEM.00989-13.

Rapid birth-and-death evolution of the xenobiotic metabolizing NAT gene family in vertebrates with evidence of adaptive selection.

Sabbagh A, Marin J, Veyssiere C, Lecompte E, Boukouvala S, Poloni E BMC Evol Biol. 2013; 13:62.

PMID: 23497148 PMC: 3601968. DOI: 10.1186/1471-2148-13-62.

References

Schmitt I, Lumbsch H . Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. PLoS One. 2009; 4(2):e4437. PMC: 2636887. DOI: 10.1371/journal.pone.0004437. View

Kroken S, Glass N, Taylor J, Yoder O, Turgeon B . Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes. Proc Natl Acad Sci U S A. 2003; 100(26):15670-5. PMC: 307626. DOI: 10.1073/pnas.2532165100. View

Trepanier L, Cribb A, Spielberg S, Ray K . Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene. Pharmacogenetics. 1999; 8(2):169-79. DOI: 10.1097/00008571-199804000-00009. View

Westwood I, Holton S, Rodrigues-Lima F, Dupret J, Bhakta S, Noble M . Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase. Biochem J. 2004; 385(Pt 2):605-12. PMC: 1134735. DOI: 10.1042/BJ20041330. View

Xu J, Saunders C, Hu P, Grant R, Boekhout T, Kuramae E . Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Proc Natl Acad Sci U S A. 2007; 104(47):18730-5. PMC: 2141845. DOI: 10.1073/pnas.0706756104. View

Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I . Arylamine N-acetyltransferases in mycobacteria. Curr Drug Metab. 2008; 9(6):510-9. PMC: 2764864. DOI: 10.2174/138920008784892100. View

Rogozin I, Sverdlov A, Babenko V, Koonin E . Analysis of evolution of exon-intron structure of eukaryotic genes. Brief Bioinform. 2005; 6(2):118-34. DOI: 10.1093/bib/6.2.118. View

Rodrigues-Lima F, Dupret J . In silico sequence analysis of arylamine N-acetyltransferases: evidence for an absence of lateral gene transfer from bacteria to vertebrates and first description of paralogs in bacteria. Biochem Biophys Res Commun. 2002; 293(2):783-92. DOI: 10.1016/S0006-291X(02)00299-1. View

Silar P, Barreau C, Debuchy R, Kicka S, Turcq B, Sainsard-Chanet A . Characterization of the genomic organization of the region bordering the centromere of chromosome V of Podospora anserina by direct sequencing. Fungal Genet Biol. 2003; 39(3):250-63. DOI: 10.1016/s1087-1845(03)00025-2. View

10.

Lamour K, Win J, Kamoun S . Oomycete genomics: new insights and future directions. FEMS Microbiol Lett. 2007; 274(1):1-8. DOI: 10.1111/j.1574-6968.2007.00786.x. View

11.

Zeng Q, Morales A, Cottarel G . Fungi and humans: closer than you think. Trends Genet. 2001; 17(12):682-4. DOI: 10.1016/s0168-9525(01)02498-2. View

12.

Glenn A, Bacon C . FDB2 encodes a member of the arylamine N-acetyltransferase family and is necessary for biotransformation of benzoxazolinones by Fusarium verticillioides. J Appl Microbiol. 2009; 107(2):657-71. DOI: 10.1111/j.1365-2672.2009.04246.x. View

13.

Richards T, Dacks J, Jenkinson J, Thornton C, Talbot N . Evolution of filamentous plant pathogens: gene exchange across eukaryotic kingdoms. Curr Biol. 2006; 16(18):1857-64. DOI: 10.1016/j.cub.2006.07.052. View

14.

Fang S, Chung J, Chang W, Chang S . Evidence for arylamine N-acetyltransferase activity in the fungi Candida albicans. Toxicol Lett. 1997; 92(2):109-16. DOI: 10.1016/s0378-4274(97)00037-4. View

15.

Genereux D, Logsdon Jr J . Much ado about bacteria-to-vertebrate lateral gene transfer. Trends Genet. 2003; 19(4):191-5. DOI: 10.1016/S0168-9525(03)00055-6. View

16.

Voelker D, Stetefeld N, Schirmer K, Scholz S . The role of cyp1a and heme oxygenase 1 gene expression for the toxicity of 3,4-dichloroaniline in zebrafish (Danio rerio) embryos. Aquat Toxicol. 2007; 86(1):112-20. DOI: 10.1016/j.aquatox.2007.10.007. View

17.

Rodrigues-Lima F, Dairou J, Diaz C, Rubio M, Sim E, Spaink H . Cloning, functional expression and characterization of Mesorhizobium loti arylamine N-acetyltransferases: rhizobial symbiosis supplies leguminous plants with the xenobiotic N-acetylation pathway. Mol Microbiol. 2006; 60(2):505-12. DOI: 10.1111/j.1365-2958.2006.05114.x. View

18.

Espagne E, Lespinet O, Malagnac F, Da Silva C, Jaillon O, Porcel B . The genome sequence of the model ascomycete fungus Podospora anserina. Genome Biol. 2008; 9(5):R77. PMC: 2441463. DOI: 10.1186/gb-2008-9-5-r77. View

19.

Hibbett D, Binder M, Bischoff J, Blackwell M, Cannon P, Eriksson O . A higher-level phylogenetic classification of the Fungi. Mycol Res. 2007; 111(Pt 5):509-47. DOI: 10.1016/j.mycres.2007.03.004. View

20.

Arvas M, Kivioja T, Mitchell A, Saloheimo M, Ussery D, Penttila M . Comparison of protein coding gene contents of the fungal phyla Pezizomycotina and Saccharomycotina. BMC Genomics. 2007; 8:325. PMC: 2045113. DOI: 10.1186/1471-2164-8-325. View