Exploring the Nature of Desmosomal Cadherin Associations in 3D

Overview

Journal Dermatol Res Pract

Publisher Wiley

Specialty Dermatology

Date 2010 Jul 31

PMID 20672011

Citations 9

Authors

Gethin R Owen

David L Stokes

Affiliations

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Abstract

Desmosomes are a complex assembly of protein molecules that mediate adhesion between adjacent cells. Desmosome composition is well established and spatial relationships between components have been identified. Intercellular cell-cell adhesion is created by the interaction of extracellular domains of desmosomal cadherins, namely, desmocollins and desmogleins. High-resolution methods have provided insight into the structural interactions between cadherins. However, there is a lack of understanding about the architecture of the intact desmosomes and the physical principles behind their adhesive strength are unclear. Electron Tomography (ET) studies have offered three-dimensional visual data of desmosomal cadherin associations at molecular resolution. This review discusses the merits of two cadherin association models represented using ET. We discuss the possible role of sample preparation on the structural differences seen between models and the possibility of adaptive changes in the structure as a direct consequence of mechanical stress and stratification.

Citing Articles

Desmosomal Cadherins in Health and Disease.

Hegazy M, Perl A, Svoboda S, Green K Annu Rev Pathol. 2021; 17:47-72.

PMID: 34425055 PMC: 8792335. DOI: 10.1146/annurev-pathol-042320-092912.

Dsg2 Upregulation as a Rescue Mechanism in Pemphigus.

Sigmund A, Steinert L, Egu D, Bayerbach F, Waschke J, Vielmuth F Front Immunol. 2020; 11:581370.

PMID: 33193387 PMC: 7655986. DOI: 10.3389/fimmu.2020.581370.

Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering.

Fuchs M, Foresti M, Radeva M, Kugelmann D, Keil R, Hatzfeld M Cell Mol Life Sci. 2019; 76(17):3465-3476.

PMID: 30949721 PMC: 11105395. DOI: 10.1007/s00018-019-03083-8.

Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion.

Ungewiss H, Rotzer V, Meir M, Fey C, Diefenbacher M, Schlegel N Cell Mol Life Sci. 2018; 75(22):4251-4268.

PMID: 29980799 PMC: 11105603. DOI: 10.1007/s00018-018-2869-x.

Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase.

Ungewiss H, Vielmuth F, Suzuki S, Maiser A, Harz H, Leonhardt H Sci Rep. 2017; 7(1):6329.

PMID: 28740231 PMC: 5524837. DOI: 10.1038/s41598-017-06713-y.

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