Sustained Viral Load and Late Death in Rag2-/- Mice After Influenza A Virus Infection

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2010 Jul 30

PMID 20667098

Citations 20

Authors

Haiya Wu

Verena Haist

Wolfgang Baumgartner

Klaus Schughart

Affiliations

Soon will be listed here.

Abstract

The importance of the adaptive immune response for secondary influenza infections and protection from a lethal challenge after vaccination has been well documented. However, some controversy still exists concerning the specific involvement of B and T cells during a primary infection. Here, we have followed the survival, weight loss, viral load and lung pathology in Rag2-/- knock-out mice after infection with influenza A virus (H1N1). Infected wild type mice initially lost weight early after infection but then cleared the virus and recovered. Rag2-/- mice, however, showed similar weight loss kinetics in the early stages after infection but weight loss continued post infection and culminated in death. In contrast to wild type mice, Rag2-/- mice were not able to clear the virus, despite an increased inflammatory response. Furthermore, they did not recruit virus-specific lymphocytes into the lung in the later stages after infection and exhibited sustained pulmonary lesions.

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