Near-infrared Tomography of Breast Cancer Hemoglobin, Water, Lipid, and Scattering Using Combined Frequency Domain and Cw Measurement

Overview

Journal Opt Lett

Specialty Ophthalmology

Date 2010 Jul 29

PMID 20664680

Citations 13

Authors

Jia Wang

Brian W Pogue

Shudong Jiang

Keith D Paulsen

Affiliations

Soon will be listed here.

Abstract

In this study, near-IR tomography was implemented in the wavelength range from 661 to 948 nm to characterize breast tumors in vivo. Frequency-domain measurements provide amplitude and phase transmitted at wavelengths below 850 nm, where photomultiplier tube detection is efficient. Continuous-wave detection at additional longer wavelengths (903, 912, and 948 nm) was collected using a CCD-based spectrometer. Phantom validation experiments showed improved accuracy in hemoglobin and water concentrations using this technique. Three women with malignant breast tumors were studied. The addition of cw data at longer wavelengths increased the recovered contrast of water in the tumor region relative to surrounding tissue and allowed quantification of lipid.

Citing Articles

Performance assessment of MRI guided continuous wave near-infrared spectral tomography for breast imaging.

Feng J, Jiang S, Pogue B, Paulsen K Biomed Opt Express. 2022; 12(12):7657-7672.

PMID: 35003858 PMC: 8713687. DOI: 10.1364/BOE.444131.

Multi-Wavelength Fluorescence in Image-Guided Surgery, Clinical Feasibility and Future Perspectives.

van Beurden F, van Willigen D, Vojnovic B, van Oosterom M, Brouwer O, van der Poel H Mol Imaging. 2020; 19:1536012120962333.

PMID: 33125289 PMC: 7607779. DOI: 10.1177/1536012120962333.

Collagen quantification in breast tissue using a 12-wavelength near infrared spectral tomography (NIRST) system.

Zhao Y, Burger W, Zhou M, Bernhardt E, Kaufman P, Patel R Biomed Opt Express. 2017; 8(9):4217-4229.

PMID: 28966860 PMC: 5611936. DOI: 10.1364/BOE.8.004217.

Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography.

Michaelsen K, Krishnaswamy V, Shi L, Vedantham S, Karellas A, Pogue B J Biomed Opt. 2016; 21(9):91316.

PMID: 27677170 PMC: 5038925. DOI: 10.1117/1.JBO.21.9.091316.

The state of the art in breast imaging using the Twente Photoacoustic Mammoscope: results from 31 measurements on malignancies.

Heijblom M, Piras D, van den Engh F, van der Schaaf M, Klaase J, Steenbergen W Eur Radiol. 2016; 26(11):3874-3887.

PMID: 26945762 PMC: 5052314. DOI: 10.1007/s00330-016-4240-7.

References

Cerussi A, Shah N, Hsiang D, Durkin A, Butler J, Tromberg B . In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy. J Biomed Opt. 2006; 11(4):044005. DOI: 10.1117/1.2337546. View

Choe R, Corlu A, Lee K, Durduran T, Konecky S, Grosicka-Koptyra M . Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI. Med Phys. 2005; 32(4):1128-39. DOI: 10.1118/1.1869612. View

Jakubowski D, Cerussi A, Bevilacqua F, Shah N, Hsiang D, Butler J . Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study. J Biomed Opt. 2004; 9(1):230-8. DOI: 10.1117/1.1629681. View

Pifferi A, Taroni P, Torricelli A, Messina F, Cubeddu R, Danesini G . Four-wavelength time-resolved optical mammography in the 680-980-nm range. Opt Lett. 2003; 28(13):1138-40. DOI: 10.1364/ol.28.001138. View

Corlu A, Durduran T, Choe R, Schweiger M, Hillman E, Arridge S . Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography. Opt Lett. 2003; 28(23):2339-41. DOI: 10.1364/ol.28.002339. View

Fang Q, Carp S, Selb J, Boverman G, Zhang Q, Kopans D . Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression. IEEE Trans Med Imaging. 2009; 28(1):30-42. PMC: 2642986. DOI: 10.1109/TMI.2008.925082. View

Davis S, Pogue B, Springett R, Leussler C, Mazurkewitz P, Tuttle S . Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue. Rev Sci Instrum. 2008; 79(6):064302. PMC: 2678791. DOI: 10.1063/1.2919131. View

Cerussi A, Jakubowski D, Shah N, Bevilacqua F, Lanning R, Berger A . Spectroscopy enhances the information content of optical mammography. J Biomed Opt. 2002; 7(1):60-71. DOI: 10.1117/1.1427050. View

Jiang H, Xu Y, Iftimia N, Eggert J, Klove K, Baron L . Three-dimensional optical tomographic imaging of breast in a human subject. IEEE Trans Med Imaging. 2002; 20(12):1334-40. DOI: 10.1109/42.974928. View

10.

Culver J, Choe R, Holboke M, Zubkov L, Durduran T, Slemp A . Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging. Med Phys. 2003; 30(2):235-47. DOI: 10.1118/1.1534109. View

11.

Pifferi A, Swartling J, Chikoidze E, Torricelli A, Taroni P, Bassi A . Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances. J Biomed Opt. 2004; 9(6):1143-51. DOI: 10.1117/1.1802171. View

12.

Wang J, Davis S, Srinivasan S, Jiang S, Pogue B, Paulsen K . Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data. J Biomed Opt. 2008; 13(4):041305. PMC: 3018156. DOI: 10.1117/1.2952006. View

13.

van de Ven S, Elias S, Wiethoff A, van der Voort M, Leproux A, Nielsen T . Diffuse optical tomography of the breast: initial validation in benign cysts. Mol Imaging Biol. 2008; 11(2):64-70. PMC: 2696611. DOI: 10.1007/s11307-008-0176-x. View

14.

Wang J, Jiang S, Paulsen K, Pogue B . Broadband frequency-domain near-infrared spectral tomography using a mode-locked Ti:sapphire laser. Appl Opt. 2009; 48(10):D198-207. PMC: 2804890. DOI: 10.1364/ao.48.00d198. View

15.

Jiang S, Pogue B, Carpenter C, Poplack S, Wells W, Kogel C . Evaluation of breast tumor response to neoadjuvant chemotherapy with tomographic diffuse optical spectroscopy: case studies of tumor region-of-interest changes. Radiology. 2009; 252(2):551-60. PMC: 2753781. DOI: 10.1148/radiol.2522081202. View