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Ectopic Fat and Cardiovascular Disease: What is the Link?

Overview
Journal Nutr Metab Cardiovasc Dis
Publisher Elsevier
Specialties Cardiology & Vascular Diseases
Endocrinology
Nutritional Sciences
Date 2010 Jul 28
PMID 20659791
Citations 59
Authors
A Gastaldelli
G Basta
Affiliations
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Abstract

Aim: of this paper is to review the recent literature on the relationship between ectopic fat accumulation and cardiovascular disease.

Data Synthesis: Ectopic fat is an important predictor of metabolic (in particular insulin resistance) and cardiovascular disease, carrying more risk than general fat accumulation. Recent studies have shown a link between ectopic fat accumulation, as cardiac (epicardial or intra-myocardial fat) and/or visceral and/or hepatic fat, and development of atherosclerosis, coronary heart disease and hypertension.

Conclusions: Ectopic fat accumulation is not only a marker of cardiometabolic disease, since through the release of adipocitokines, lipotoxic and glucotoxic agents, participates in the crosstalk with insulin-sensitive organs leading to metabolic, cardiac and vascular dysfunctions.

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