Semen Quality and Sperm DNA Damage in Relation to Urinary Bisphenol A Among Men from an Infertility Clinic

Overview

Journal Reprod Toxicol

Specialties Reproductive Medicine
Toxicology

Date 2010 Jul 27

PMID 20656017

Citations 130

Authors

John D Meeker

Shelley Ehrlich

Thomas L Toth

Diane L Wright

Antonia M Calafat

Ana T Trisini

Xiaoyun Ye

Russ Hauser

Affiliations

Soon will be listed here.

Abstract

Bisphenol A (BPA) impairs spermatogenesis in animals, but human studies are lacking. We measured urinary BPA concentrations, semen quality, and sperm DNA damage (comet assay) in 190 men recruited through an infertility clinic. BPA was detected in 89% of samples, with a median (interquartile range [IQR]) concentration of 1.3 (0.8-2.5) ng/mL. Urinary BPA concentration was associated with slightly elevated, though not statistically significant, odds for below reference sperm concentration, motility, and morphology. When modeled as continuous dependent variables, an IQR increase in urinary BPA concentration was associated with declines in sperm concentration, motility, and morphology of 23% (95%CI -40%, -0.3%), 7.5% (-17%, +1.5%), and 13% (-26%, -0.1%), respectively, along with a 10% (0.03%, 19%) increase in sperm DNA damage measured as the percentage of DNA in comet tail. In conclusion, urinary BPA may be associated with declined semen quality and increased sperm DNA damage, but confirmatory studies are needed.

Citing Articles

Oxidative Stress and Keap1-Nrf2 Pathway Involvement in Bisphenol A-Induced Liver Damage in Rats.

Tang J, Wang K, Shen D, Li C Toxics. 2025; 12(12.

PMID: 39771079 PMC: 11678961. DOI: 10.3390/toxics12120864.

Environmentally-relevant doses of bisphenol A and S exposure in utero disrupt germ cell programming across generations resolved by single nucleus multi-omics.

Zhao L, Shi M, Winuthayanon S, MacLean 2nd J, Hayashi K bioRxiv. 2024; .

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The impact of Bisphenol-A on human reproductive health.

Salami E, Rotimi O Toxicol Rep. 2024; 13:101773.

PMID: 39526236 PMC: 11550589. DOI: 10.1016/j.toxrep.2024.101773.

The effects of bisphenol A and its analogs on steroidogenesis in MA-10 Leydig cells and KGN granulosa cells†.

Iskandarani L, Romanelli S, Hales B, Robaire B Biol Reprod. 2024; 112(2):399-414.

PMID: 39520287 PMC: 11833478. DOI: 10.1093/biolre/ioae165.

Bisphenol AP Exposure-Induced Inflammatory Response in Zebrafish Embryos Revealed by Transcriptomic Analysis.

Ding Q, Wang H Environ Health (Wash). 2024; 2(6):373-380.

PMID: 39473470 PMC: 11504550. DOI: 10.1021/envhealth.4c00028.

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