Opisthorchiasis and Opisthorchis-associated Cholangiocarcinoma in Thailand and Laos

Overview

Journal Acta Trop

Publisher Elsevier

Specialty Tropical Medicine

Date 2010 Jul 27

PMID 20655862

Citations 144

Authors

Banchob Sripa

Jeffrey M Bethony

Paiboon Sithithaworn

Sasithorn Kaewkes

Eimorn Mairiang

Alex Loukas

Jason Mulvenna

Thewarach Laha

Peter J Hotez

Paul J Brindley

Affiliations

Soon will be listed here.

Abstract

Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and the Lao People's Democratic Republic (Lao PDR; Laos). Currently, more than 600 million people are at risk of infection with these fish-borne trematodes and/or their close relatives. Opisthorchiasis has been studied extensively in Thailand, where about 8 million people are infected with the liver fluke. Here we review the pathogenesis, control and re-emergence of O. viverrini infection, in particular in Thailand and, to a lesser extent in Lao PDR given the contiguous geographical range of O. viverrini through these two regions. We also review the association of O. viverrini infection and cholangiocarcinoma, bile duct cancer, and highlight new findings on pathogenesis of liver fluke-induced cholangiocarcinogenesis. Last, we comment on national control strategies in Thailand for the control of O. viverrini infection aimed at reduction in the prevalence of O. viverrini-associated liver cancer in the longer term.

Citing Articles

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