Paul J Brindley
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Explore the profile of Paul J Brindley including associated specialties, affiliations and a list of published articles.
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253
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7425
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Recent Articles
1.
Brindley P, Hotez P, Kamhawi S
PLoS Negl Trop Dis
. 2025 Feb;
19(2):e0012794.
PMID: 39977425
PLOS Neglected Tropical Diseases (PLOS NTDs) publishes research devoted to pathogenesis and other clinical aspects, epidemiology, prevention, diagnosis, treatment, and control of the neglected tropical diseases (NTDs), as well as...
2.
Wong Y, Rosa B, Becker L, Camberis M, LeGros G, Zhan B, et al.
PLoS Negl Trop Dis
. 2025 Jan;
19(1):e0012780.
PMID: 39832284
More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management...
3.
Kenney E, Mann V, Ittiprasert W, Rosa B, Mitreva M, Bracken B, et al.
Front Parasitol
. 2025 Jan;
1():950744.
PMID: 39816473
Intricate molecular communication between schistosome flatworms and their mammalian host, as well as between paired male and female schistosomes has shaped the secreted proteome of these flatworms. Whereas the schistosome...
4.
Wu N, Bayatpour S, Hylemon P, Aseem S, Aseem S, Brindley P, et al.
Am J Pathol
. 2024 Dec;
195(3):397-408.
PMID: 39730075
Cholangiocarcinoma (CCA) is a rare but highly malignant carcinoma of bile duct epithelial cells with a poor prognosis. The major risk factors of CCA carcinogenesis and progression are cholestatic liver...
5.
Smout M, Laha T, Chaiyadet S, Brindley P, Loukas A
Trends Parasitol
. 2024 Nov;
40(12):1183-1196.
PMID: 39521672
Liver fluke infection is a major risk for cholangiocarcinoma (CCA). It has been established that the Asian liver flukes, Clonorchis sinensis and Opisthorchis viverrini secrete growth factors, digestive enzymes, and...
6.
Ittiprasert W, Brindley P
Trends Parasitol
. 2024 Oct;
40(11):1016-1028.
PMID: 39426911
CRISPR genome editing is actively used for schistosomes and other flukes. The ability to genetically manipulate these flatworms enables deeper investigation of their (patho)biological nature. CRISPR gene knockout (KO) demonstrated...
7.
Wisitpongpun P, Buakaew W, Pongcharoen S, Apiratmateekul N, Potup P, Daowtak K, et al.
PeerJ
. 2024 Sep;
12:e18090.
PMID: 39308806
Background: Tumor-associated macrophages (TAMs) play a critical function in the development of tumors and are associated with protumor M2 phenotypes. Shifting TAMs towards antitumor M1 phenotypes holds promise for tumor...
8.
Multiplexed CRISPR-Cas9 protocol for large transgene integration into the Schistosoma mansoni genome
Ittiprasert W, Moescheid M, Mann V, Brindley P
STAR Protoc
. 2024 Feb;
5(1):102886.
PMID: 38354082
Precise, on-target CRISPR-Cas9 genome editing has been shown in Schistosoma mansoni, involving both non-homology end joining and homology-directed repair pathways. Here, we present a multiplexed CRISPR-Cas9 protocol for large transgene...
9.
10.
Jorge F, Brealey J, Brindley P, Buysse M, Cantacessi C, Duron O, et al.
ISME Commun
. 2023 Nov;
2(1):9.
PMID: 37938691
The symbiont-associated (SA) environmental package is a new extension to the minimum information about any (x) sequence (MIxS) standards, established by the Parasite Microbiome Project (PMP) consortium, in collaboration with...