Alpha 2.0
Login Register
» Articles » PMID: 20655462

SRD5A3: A Surprising Role in Glycosylation

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2010 Jul 27
PMID 20655462
Citations 29
Authors
Ashlee R Stiles
David W Russell
Affiliations
Soon will be listed here.
Abstract

The steroid 5alpha-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.

Citing Articles

Immune and Non-immune Interactions in the Pathogenesis of Androgenetic Alopecia.

Xiao Y, Zhang Y, Deng S, Yang X, Yao X Clin Rev Allergy Immunol. 2025; 68(1):22.

PMID: 40024940 DOI: 10.1007/s12016-025-09034-5.

Analysis of the implication of steroid 5 alpha-reductase 3 on prognosis and immune microenvironment in Liver Hepatocellular Carcinoma.

Lu Y, Liu Z, Zheng Y, Liu X, Liu X, Chen N Ann Med. 2024; 56(1):2408463.

PMID: 39340288 PMC: 11441025. DOI: 10.1080/07853890.2024.2408463.

Evolution, classification, structure, and functional diversification of steroid 5α-reductase family in eukaryotes.

Ali K, Li W, Wu G Heliyon. 2024; 10(14):e34322.

PMID: 39108866 PMC: 11301207. DOI: 10.1016/j.heliyon.2024.e34322.

Insights into immune microenvironment and therapeutic targeting in androgen-associated prostate cancer subtypes.

Huang L, Xie Y, Jiang S, Dai T, Xu Z, Shan H Sci Rep. 2024; 14(1):18036.

PMID: 39098988 PMC: 11298543. DOI: 10.1038/s41598-024-68863-0.

Is There an Association between 5a Reductase Inhibitors and Metabolic Syndrome? A Narrative Review of the Literature.

Ziogou A, Giannakodimos A, Mitakidi E, Konstantinos T, Giannakodimos I Rev Recent Clin Trials. 2024; 19(4):229-235.

PMID: 38910423 DOI: 10.2174/0115748871303638240529160610.

References
1.
Wilson J . Sexual differentiation. Annu Rev Physiol. 1978; 40:279-306. DOI: 10.1146/annurev.ph.40.030178.001431. View
2.
Russell D, Wilson J . Steroid 5 alpha-reductase: two genes/two enzymes. Annu Rev Biochem. 1994; 63:25-61. DOI: 10.1146/annurev.bi.63.070194.000325. View
3.
Langlois V, Zhang D, Cooke G, Trudeau V . Evolution of steroid-5alpha-reductases and comparison of their function with 5beta-reductase. Gen Comp Endocrinol. 2009; 166(3):489-97. DOI: 10.1016/j.ygcen.2009.08.004. View
4.
Cantagrel V, Lefeber D, Ng B, Guan Z, Silhavy J, Bielas S . SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell. 2010; 142(2):203-17. PMC: 2940322. DOI: 10.1016/j.cell.2010.06.001. View
5.
Moon Y, Horton J . Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. J Biol Chem. 2002; 278(9):7335-43. DOI: 10.1074/jbc.M211684200. View