Fetal and Maternal Factors Associated with Infant Mortality in Vervet Monkeys

Overview

Journal J Med Primatol

Publisher Wiley

Date 2010 Jul 20

PMID 20637047

Citations 8

Authors

K Kavanagh

B L Dozier

T J Chavanne

L A Fairbanks

M J Jorgensen

J R Kaplan

Affiliations

Soon will be listed here.

Abstract

Background: Causes of infant death remain unknown in significant proportions of human and non-human primate pregnancies.

Methods: A closed breeding colony with high rates of infant mortality had pregnancies assessed (n=153) by fetal measurements and maternal characteristics. Infant outcome was classified as neonatal death (stillborn or died <48 hours from birth), postnatal death (died 2-30 days) or surviving (alive after 30 days).

Results: Fetal size did not predict outcome. Poor maternal glycemic control and low social ranking increased odds for adverse outcome (OR=3.72, P=0.01 and 2.27, P=0.04, respectively). Male sex was over-represented in stillbirths (P=0.04), and many were macrosomic, but size did not associate with maternal glycemic control measured as glycated hemoglobin A1c. Postnatally dead infants were smaller (P<0.01), which associated with behavioral factors and glycemic control.

Conclusions: Fetal growth estimates predicted gestational age but not fetal outcome. Maternal social status and metabolic health, particularly glycemic control, increased risks of adverse pregnancy outcome.

Citing Articles

The early life microbiota mediates maternal effects on offspring growth in a nonhuman primate.

Petrullo L, Baniel A, Jorgensen M, Sams S, Snyder-Mackler N, Lu A iScience. 2022; 25(3):103948.

PMID: 35265817 PMC: 8898918. DOI: 10.1016/j.isci.2022.103948.

Advanced maternal age impacts physiologic adaptations to pregnancy in vervet monkeys.

Plant M, Armstrong C, Ruggiero A, Sherrill C, Uberseder B, Jeffries R Geroscience. 2020; 42(6):1649-1661.

PMID: 32588342 PMC: 7732933. DOI: 10.1007/s11357-020-00219-8.

Transcriptomic Analysis of Cell-free Fetal RNA in the Amniotic Fluid of Vervet Monkeys ().

Jasinska A, Rostamian D, Davis A, Kavanagh K Comp Med. 2020; 70(1):67-74.

PMID: 31969210 PMC: 7024774. DOI: 10.30802/AALAS-CM-19-000037.

Microbial translocation into amniotic fluid of vervet monkeys is common and unrelated to adverse infant outcomes.

Kendziorski J, Sherrill C, Davis A, Kavanagh K J Med Primatol. 2019; 48(6):367-369.

PMID: 31338846 PMC: 6829022. DOI: 10.1111/jmp.12432.

Hematology and Clinical Chemistry Measures During and After Pregnancy and Age- and Sex-Specific Reference Intervals in African Green Monkeys (Chlorocebus aethiops sabaeus).

Chichester L, Gee M, Jorgensen M, Kaplan J J Am Assoc Lab Anim Sci. 2015; 54(4):359-67.

PMID: 26224434 PMC: 4521568.

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