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A Novel Brucella Isolate in Association with Two Cases of Stillbirth in Non-human Primates - First Report

Overview
Journal J Med Primatol
Publisher Wiley
Date 2009 Feb 4
PMID 19187435
Citations 24
Authors
Natalia E Schlabritz-Loutsevitch
Adrian M Whatmore
Christine R Quance
Mark S Koylass
L Bill Cummins
Edward J Dick Jr
Cathy L Snider
David Cappelli
Jeffrey L Ebersole
Peter W Nathanielsz
Gene B Hubbard
Affiliations
Soon will be listed here.
Abstract

Background: Brucellosis is veterinary and human health problem.

Methods: A 13-year-old wild caught multiparous and an 8-year-old colony-born nulliparous baboon had stillbirths in the second trimester of pregnancy. Culture isolates from both postpartum uteruses were characterized using traditional biochemical analysis, PCR, and multilocus sequencing.

Results: The isolates morphologically resembled Brucella although their phenotypic characteristics were not consistent with any currently described species. The isolates represent a novel lineage within the genus with unique alleles, not previously seen in surveys of greater than 300 isolates representing the known diversity of the genus, present at 5/9 loci examined.

Conclusions: The described cases are to the best of our knowledge the first presentation of a naturally acquired Brucella infection in non-human primates associated with stillbirths from the same colony where Brucella seropositivity in the baboons was described 45 years ago. The organism appears to represent a previously undescribed Brucella species.

Citing Articles

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Islam M, El Zowalaty M, Van Vliet A, Thakur S, Khatun M, Saha S Microbiol Resour Announc. 2019; 8(24).

PMID: 31196923 PMC: 6554610. DOI: 10.1128/MRA.00446-19.

Predominance of Brucella abortus antibodies among women with spontaneous abortion in the city of Mwanza: unrecognized link or coincidence?.

Mujuni F, Andrew V, Mngumi E, Chibwe E, Mshana S, Mirambo M BMC Res Notes. 2018; 11(1):792.

PMID: 30400996 PMC: 6219096. DOI: 10.1186/s13104-018-3906-4.

A MALDI-TOF MS database with broad genus coverage for species-level identification of Brucella.

Mesureur J, Arend S, Celliere B, Courault P, Cotte-Pattat P, Totty H PLoS Negl Trop Dis. 2018; 12(10):e0006874.

PMID: 30335748 PMC: 6207331. DOI: 10.1371/journal.pntd.0006874.

Comparisons of brucellosis between human and veterinary medicine.

Hull N, Schumaker B Infect Ecol Epidemiol. 2018; 8(1):1500846.

PMID: 30083304 PMC: 6063340. DOI: 10.1080/20008686.2018.1500846.

Uterine Microbiota: Residents, Tourists, or Invaders?.

Baker J, Chase D, Herbst-Kralovetz M Front Immunol. 2018; 9:208.

PMID: 29552006 PMC: 5840171. DOI: 10.3389/fimmu.2018.00208.

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