The Neuronal Origin of Prostaglandin Released from the Rabbit Portal Vein in Response to Electrical Stimulation

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1978 May 1

PMID 206308

Citations 2

Authors

R Greenberg

Affiliations

Soon will be listed here.

Abstract

Transmural electrical stimulation of the isolated portal vein of the rabbit was accompanied by the release of a prostaglandin-like substance (PLS). Thin layer chromatography coupled with bioassay indicated that this substance was probably prostaglandin E2 (PGE2). 2 Indomethacin potentiated the response of the portal vein to electrical stimulation at 2 Hz and abolished the release of the PLS. 3 There was no significant change in the amount of PLS released from the portal vein in response to electrical stimulation at 2 Hz when the contractile response of the portal vein was prevented by pretreatment with phentolamine or guanthidine. 4 In vitro denervation of the portal vein with 6-hydroxydopamine or the omission of Ca2+ from the bathing solution caused a significant reduction in the amount of PLS released from the portal vein in response to electrical stimulation at 2 hertz. 5 It is concluded that electrical stimulation of the isolated portal vein of the rabbit is accompanied by the release of a PLS, probably PGE2, from a neuronal source. The synthesis and release of the PLS is Ca2+ -dependent.

Citing Articles

A possible negative feedback control of excitatory transmission via prostaglandins in canine small intestine.

Nakahata N, Nakanishi H, Suzuki T Br J Pharmacol. 1980; 68(3):393-8.

PMID: 6301592 PMC: 2044212. DOI: 10.1111/j.1476-5381.1980.tb14552.x.

Prostaglandin-induced inhibition of acetylcholine release from neuronal elements of dog tracheal tissue.

Inoue T, Ito Y, Takeda K J Physiol. 1984; 349:553-70.

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References

Hedqvist P . Basic mechanisms of prostaglandin action on autonomic neurotransmission. Annu Rev Pharmacol Toxicol. 1977; 17:259-79. DOI: 10.1146/annurev.pa.17.040177.001355. View

Aprigliano O, Rybarczyk K, Hermsmeyer K, VAN ORDEN L . Adrenergic neuronal degeneration induced in portal vein and caudal artery by 6-hydroxydopamine in vitro. J Pharmacol Exp Ther. 1976; 198(3):578-88. View

Aprigliano O, Hermsmeyer K . In vitro denervation of the portal vein and caudal artery of the rat. J Pharmacol Exp Ther. 1976; 198(3):568-77. View

Hedqvist P, VON EULER U . Prostaglandin controls neuromuscular transmission in guinea-pig vas deferens. Nat New Biol. 1972; 236(65):113-5. DOI: 10.1038/newbio236113a0. View

PIPER P, Vane J . The release of prostaglandins from lung and other tissues. Ann N Y Acad Sci. 1971; 180:363-85. DOI: 10.1111/j.1749-6632.1971.tb53205.x. View

NEEDLEMAN P, Douglas Jr J, Jakschik B, Stoecklein P, Johnson Jr E . Release of renal prostaglandin by catecholamines: relationship to renal endocrine function. J Pharmacol Exp Ther. 1974; 188(2):453-60. View

Hughes J . Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens. Br J Pharmacol. 1972; 44(3):472-91. PMC: 1665830. DOI: 10.1111/j.1476-5381.1972.tb07285.x. View

Hedqvist P, Stjarne L, Wennmalm A . Facilitation of sympathetic neurotransmission in the cat spleen after inhibition of prostaglandin synthesis. Acta Physiol Scand. 1971; 83(3):430-2. DOI: 10.1111/j.1748-1716.1971.tb05099.x. View

Samuelsson B, Wennmalm A . Increased nerve stimulation induced release of noradrenaline from the rabbit heart after inhibition of prostaglandin synthesis. Acta Physiol Scand. 1971; 83(2):163-8. DOI: 10.1111/j.1748-1716.1971.tb05065.x. View

10.

Chanh P, Junstad M, Wennmalm A . Augmented noradrenaline release following nerve stimulation after inhibition of prostaglandin synthesis with indomethacin. Acta Physiol Scand. 1972; 86(4):563-7. DOI: 10.1111/j.1748-1716.1972.tb05357.x. View

11.

Greenberg R . The effects of indomethacin and eicosa-5,8,11,14-tetraynoic acid on the response of the rabbit portal vein to electrical stimulation. Br J Pharmacol. 1974; 52(1):61-8. PMC: 1776927. DOI: 10.1111/j.1476-5381.1974.tb09687.x. View

12.

Fredholm B, Hedqvist P . Increased release of noradrenaline from stimulated guinea pig vas deferens after indomethacin treatment. Acta Physiol Scand. 1973; 87(4):570-2. DOI: 10.1111/j.1748-1716.1973.tb05424.x. View

13.

Stjarne L . Prostaglandin E restricting noradrenaline secretion--neural in origin?. Acta Physiol Scand. 1972; 86(4):574-6. DOI: 10.1111/j.1748-1716.1972.tb05360.x. View

14.

Davies B, Horton E, Withrington P . The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation. Br J Pharmacol Chemother. 1968; 32(1):127-35. PMC: 1570284. DOI: 10.1111/j.1476-5381.1968.tb00436.x. View

15.

Kunze H, VOGT W . Significance of phospholipase A for prostaglandin formation. Ann N Y Acad Sci. 1971; 180:123-5. DOI: 10.1111/j.1749-6632.1971.tb53191.x. View

16.

Gilmore N, Vane J, Wyllie J . Prostaglandins released by the spleen. Nature. 1968; 218(5147):1135-40. DOI: 10.1038/2181135a0. View