Circadian Clocks in the Ovary

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2010 Jul 6

PMID 20599392

Citations 38

Authors

Michael T Sellix

Michael Menaker

Affiliations

Soon will be listed here.

Abstract

Clock gene expression has been observed in tissues of the hypothalamic-pituitary-gonadal (HPG) axis. Whereas the contribution of hypothalamic oscillators to the timing of reproductive biology is well known, the role of peripheral oscillators like those in the ovary is less clear. Circadian clocks in the ovary might play a role in the timing of ovulation. Disruption of the clock in ovarian cells or desynchrony between ovarian clocks and circadian oscillators elsewhere in the body may contribute to the onset and progression of various reproductive pathologies. In this paper, we review evidence for clock function in the ovary across a number of species and offer a novel perspective into the role of this clock in normal ovarian physiology and in diseases that negatively affect fertility.

Citing Articles

Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound.

Britz S, Nelson S, Earhart K, Pru J, Schmitt E J Circadian Rhythms. 2024; 22:4.

PMID: 39712938 PMC: 11661015. DOI: 10.5334/jcr.249.

Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency.

Le D, Ngo M, Kuo Y, Chen S, Lin C, Ling T J Biomed Sci. 2024; 31(1):95.

PMID: 39390588 PMC: 11468397. DOI: 10.1186/s12929-024-01085-8.

Exploring the Link between Premature Ovarian Insufficiency, Insomnia and Circadian Pathways.

Kloster A, Adami L, Moyses-Oliveira M, Hachul H, Andersen M, Tufik S JBRA Assist Reprod. 2024; 28(4):567-589.

PMID: 39254468 PMC: 11622404. DOI: 10.5935/1518-0557.20240052.

Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling.

Weng L, Hong H, Zhang Q, Xiao C, Zhang Q, Wang Q Adv Sci (Weinh). 2024; 11(41):e2402393.

PMID: 39229959 PMC: 11538700. DOI: 10.1002/advs.202402393.

The contribution of circadian clock to the biological processes.

Luo B, Song J, Zhang J, Han J, Zhou X, Chen L Front Mol Biosci. 2024; 11:1387576.

PMID: 38903177 PMC: 11187296. DOI: 10.3389/fmolb.2024.1387576.

References

Sellix M, Yoshikawa T, Menaker M . A circadian egg timer gates ovulation. Curr Biol. 2010; 20(6):R266-7. PMC: 2888283. DOI: 10.1016/j.cub.2010.01.045. View

Yoo S, Yamazaki S, Lowrey P, Shimomura K, Ko C, Buhr E . PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A. 2004; 101(15):5339-46. PMC: 397382. DOI: 10.1073/pnas.0308709101. View

Borgs L, Beukelaers P, Vandenbosch R, Belachew S, Nguyen L, Malgrange B . Cell "circadian" cycle: new role for mammalian core clock genes. Cell Cycle. 2009; 8(6):832-7. DOI: 10.4161/cc.8.6.7869. View

Resuehr D, Wildemann U, Sikes H, Olcese J . E-box regulation of gonadotropin-releasing hormone (GnRH) receptor expression in immortalized gonadotrope cells. Mol Cell Endocrinol. 2007; 278(1-2):36-43. DOI: 10.1016/j.mce.2007.08.008. View

Yoshimura T, Suzuki Y, Makino E, Suzuki T, Kuroiwa A, Matsuda Y . Molecular analysis of avian circadian clock genes. Brain Res Mol Brain Res. 2000; 78(1-2):207-15. DOI: 10.1016/s0169-328x(00)00091-7. View

Dolatshad H, Campbell E, OHara L, Maywood E, Hastings M, Johnson M . Developmental and reproductive performance in circadian mutant mice. Hum Reprod. 2005; 21(1):68-79. DOI: 10.1093/humrep/dei313. View

Rafnsson V, Tulinius H, Jonasson J, Hrafnkelsson J . Risk of breast cancer in female flight attendants: a population-based study (Iceland). Cancer Causes Control. 2001; 12(2):95-101. DOI: 10.1023/a:1008983416836. View

Yamazaki S, Numano R, Abe M, Hida A, Takahashi R, Ueda M . Resetting central and peripheral circadian oscillators in transgenic rats. Science. 2000; 288(5466):682-5. DOI: 10.1126/science.288.5466.682. View

Resuehr H, Resuehr D, Olcese J . Induction of mPer1 expression by GnRH in pituitary gonadotrope cells involves EGR-1. Mol Cell Endocrinol. 2009; 311(1-2):120-5. DOI: 10.1016/j.mce.2009.07.005. View

10.

Miller B, Olson S, Turek F, Levine J, Horton T, Takahashi J . Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy. Curr Biol. 2004; 14(15):1367-73. PMC: 3756147. DOI: 10.1016/j.cub.2004.07.055. View

11.

Takahashi J, Hong H, Ko C, McDearmon E . The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet. 2008; 9(10):764-75. PMC: 3758473. DOI: 10.1038/nrg2430. View

12.

Wiegand S, Terasawa E, Bridson W . Persistent estrus and blockade of progesterone-induced LH release follows lesions which do not damage the suprachiasmatic nucleus. Endocrinology. 1978; 102(5):1645-8. DOI: 10.1210/endo-102-5-1645. View

13.

Leclerc G, Boockfor F . Pulses of prolactin promoter activity depend on a noncanonical E-box that can bind the circadian proteins CLOCK and BMAL1. Endocrinology. 2005; 146(6):2782-90. DOI: 10.1210/en.2005-0100. View

14.

de la Iglesia H, Schwartz W . Minireview: timely ovulation: circadian regulation of the female hypothalamo-pituitary-gonadal axis. Endocrinology. 2005; 147(3):1148-53. DOI: 10.1210/en.2005-1311. View

15.

Stephan F, Zucker I . Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci U S A. 1972; 69(6):1583-6. PMC: 426753. DOI: 10.1073/pnas.69.6.1583. View

16.

Boden M, Varcoe T, Voultsios A, Kennaway D . Reproductive biology of female Bmal1 null mice. Reproduction. 2010; 139(6):1077-90. DOI: 10.1530/REP-09-0523. View

17.

Yoshikawa T, Sellix M, Pezuk P, Menaker M . Timing of the ovarian circadian clock is regulated by gonadotropins. Endocrinology. 2009; 150(9):4338-47. PMC: 2736075. DOI: 10.1210/en.2008-1280. View

18.

Ko C, Takahashi J . Molecular components of the mammalian circadian clock. Hum Mol Genet. 2006; 15 Spec No 2:R271-7. DOI: 10.1093/hmg/ddl207. View

19.

Filipski E, Delaunay F, King V, Wu M, Claustrat B, Grechez-Cassiau A . Effects of chronic jet lag on tumor progression in mice. Cancer Res. 2004; 64(21):7879-85. DOI: 10.1158/0008-5472.CAN-04-0674. View

20.

Karman B, Tischkau S . Circadian clock gene expression in the ovary: Effects of luteinizing hormone. Biol Reprod. 2006; 75(4):624-32. DOI: 10.1095/biolreprod.106.050732. View