Nanoparticle-mediated Brain-specific Drug Delivery, Imaging, and Diagnosis

Overview

Journal Pharm Res

Specialties Pharmacology
Pharmacy

Date 2010 Jul 2

PMID 20593303

Citations 58

Authors

Hu Yang

Affiliations

Soon will be listed here.

Abstract

Central nervous system (CNS) diseases represent the largest and fastest-growing area of unmet medical need. Nanotechnology plays a unique instrumental role in the revolutionary development of brain-specific drug delivery, imaging, and diagnosis. With the aid of nanoparticles of high specificity and multifunctionality, such as dendrimers and quantum dots, therapeutics, imaging agents, and diagnostic molecules can be delivered to the brain across the blood-brain barrier (BBB), enabling considerable progress in the understanding, diagnosis, and treatment of CNS diseases. Nanoparticles used in the CNS for drug delivery, imaging, and diagnosis are reviewed, as well as their administration routes, toxicity, and routes to cross the BBB. Future directions and major challenges are outlined.

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