Clinical and Preclinical Translation of Cell-based Therapies Using Adipose Tissue-derived Cells

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2010 Jul 1

PMID 20587076

Citations 101

Authors

Jeffrey M Gimble

Farshid Guilak

Bruce A Bunnell

Affiliations

Soon will be listed here.

Abstract

Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture-expanded, adipose-derived stromal/stem cells in vitro and in animal models. This body of work has provided evidence supporting clinical translational applications of adipose-derived cells in safety and efficacy trials. The present article reviews the case reports and phase I-III clinical evidence using autologous adipose-derived cells that have been published, to date, in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines. Future directions and challenges facing the field are discussed and evaluated.

Citing Articles

Preclinical Assessment of Safety and Efficacy of Deferoxamine (DFO)-pretreated Feline Adipose Mesenchymal Stem Cells.

Teng H, Cho M, Ma Z, Ji X, Jin S, Zhou Y In Vivo. 2024; 39(1):267-279.

PMID: 39740892 PMC: 11705137. DOI: 10.21873/invivo.13825.

Subcutaneous adipose tissue: Implications in dermatological diseases and beyond.

Ziadlou R, Pandian G, Hafner J, Akdis C, Stingl G, Maverakis E Allergy. 2024; 79(12):3310-3325.

PMID: 39206504 PMC: 11657049. DOI: 10.1111/all.16295.

Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells: A systematic review.

Mundluru V, Naidu M, Mundluru R, Jeyaraman N, Muthu S, Ramasubramanian S World J Methodol. 2024; 14(2):94562.

PMID: 38983657 PMC: 11229868. DOI: 10.5662/wjm.v14.i2.94562.

Extracellular Vesicles from Adipose Tissue-Derived Stromal Cells Stimulate Angiogenesis in a Scaffold-Dependent Fashion.

Getova V, Orozco-Garcia E, Palmers S, Krenning G, Narvaez-Sanchez R, Harmsen M Tissue Eng Regen Med. 2024; 21(6):881-895.

PMID: 38976146 PMC: 11286612. DOI: 10.1007/s13770-024-00650-4.

vascularized immunocompetent patient-derived model to test cancer therapies.

Le H, Deforges J, Hua G, Idoux-Gillet Y, Ponte C, Lindner V iScience. 2023; 26(10):108094.

PMID: 37860774 PMC: 10582498. DOI: 10.1016/j.isci.2023.108094.

References

Gimble J . The function of adipocytes in the bone marrow stroma. New Biol. 1990; 2(4):304-12. View

Cai L, Johnstone B, Cook T, Tan J, Fishbein M, Chen P . IFATS collection: Human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function. Stem Cells. 2008; 27(1):230-7. PMC: 2936459. DOI: 10.1634/stemcells.2008-0273. View

Cui L, Yin S, Liu W, Li N, Zhang W, Cao Y . Expanded adipose-derived stem cells suppress mixed lymphocyte reaction by secretion of prostaglandin E2. Tissue Eng. 2007; 13(6):1185-95. DOI: 10.1089/ten.2006.0315. View

Jack G, Almeida F, Zhang R, Alfonso Z, ZuK P, Rodriguez L . Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction. J Urol. 2005; 174(5):2041-5. DOI: 10.1097/01.ju.0000176489.96993.84. View

Matsumoto D, Sato K, Gonda K, Takaki Y, Shigeura T, Sato T . Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng. 2007; 12(12):3375-82. DOI: 10.1089/ten.2006.12.3375. View

Gimble J, Guilak F . Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy. 2003; 5(5):362-9. DOI: 10.1080/14653240310003026. View

Garcia-Olmo D, Garcia-Arranz M, Herreros D, Pascual I, Peiro C, Rodriguez-Montes J . A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum. 2005; 48(7):1416-23. DOI: 10.1007/s10350-005-0052-6. View

Planat-Benard V, Silvestre J, Cousin B, Andre M, Nibbelink M, Tamarat R . Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation. 2004; 109(5):656-63. DOI: 10.1161/01.CIR.0000114522.38265.61. View

Rigotti G, Marchi A, Galie M, Baroni G, Benati D, Krampera M . Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007; 119(5):1409-1422. DOI: 10.1097/01.prs.0000256047.47909.71. View

10.

Taxonera C, Schwartz D, Garcia-Olmo D . Emerging treatments for complex perianal fistula in Crohn's disease. World J Gastroenterol. 2009; 15(34):4263-72. PMC: 2744181. DOI: 10.3748/wjg.15.4263. View

11.

Frisbie D, Kisiday J, Kawcak C, Werpy N, McIlwraith C . Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis. J Orthop Res. 2009; 27(12):1675-80. DOI: 10.1002/jor.20933. View

12.

Kang S, Lee D, Bae Y, Kim H, Baik S, Jung J . Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats. Exp Neurol. 2003; 183(2):355-66. DOI: 10.1016/s0014-4886(03)00089-x. View

13.

Lin K, Matsubara Y, Masuda Y, Togashi K, Ohno T, Tamura T . Characterization of adipose tissue-derived cells isolated with the Celution system. Cytotherapy. 2008; 10(4):417-26. DOI: 10.1080/14653240801982979. View

14.

Dragoo J, Choi J, Lieberman J, Huang J, ZuK P, Zhang J . Bone induction by BMP-2 transduced stem cells derived from human fat. J Orthop Res. 2003; 21(4):622-9. DOI: 10.1016/S0736-0266(02)00238-3. View

15.

Black L, Gaynor J, Gahring D, Adams C, Aron D, Harman S . Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet Ther. 2008; 8(4):272-84. View

16.

Bhang S, Cho S, Lim J, Kang J, Lee T, Yang H . Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs. Stem Cells. 2009; 27(8):1976-86. PMC: 5215850. DOI: 10.1002/stem.115. View

17.

Rubio D, Garcia-Castro J, Martin M, De La Fuente R, Cigudosa J, Lloyd A . Spontaneous human adult stem cell transformation. Cancer Res. 2005; 65(8):3035-9. DOI: 10.1158/0008-5472.CAN-04-4194. View

18.

Nixon A, Dahlgren L, Haupt J, Yeager A, Ward D . Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis. Am J Vet Res. 2008; 69(7):928-37. DOI: 10.2460/ajvr.69.7.928. View

19.

Patrick Jr C, Wu X . Integrin-mediated preadipocyte adhesion and migration on laminin-1. Ann Biomed Eng. 2003; 31(5):505-14. DOI: 10.1114/1.1566446. View

20.

Bai X, Yan Y, Song Y, Seidensticker M, Rabinovich B, Metzele R . Both cultured and freshly isolated adipose tissue-derived stem cells enhance cardiac function after acute myocardial infarction. Eur Heart J. 2009; 31(4):489-501. DOI: 10.1093/eurheartj/ehp568. View