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» Articles » PMID: 20585114

Serum and Cerebrospinal Fluid Levels of Colistin in Pediatric Patients

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 2010 Jun 30
PMID 20585114
Citations 26
Authors
Charalampos Antachopoulos
Matti Karvanen
Elias Iosifidis
Britt Jansson
Diamantis Plachouras
Otto Cars
Emmanuel Roilides
Affiliations
Soon will be listed here.
Abstract

Using a liquid chromatography-tandem mass spectrometry method, the serum and cerebrospinal fluid (CSF) concentrations of colistin were determined in patients aged 1 months to 14 years receiving intravenous colistimethate sodium (60,000 to 225,000 IU/kg of body weight/day). Only in one of five courses studied (a 14-year-old receiving 225,000 IU/kg/day) did serum concentrations exceed the 2 microg/ml CLSI/EUCAST breakpoint defining susceptibility to colistin for Pseudomonas and Acinetobacter. CSF colistin concentrations were <0.2 microg/ml but increased in the presence of meningitis (approximately 0.5 microg/ml or 34 to 67% of serum levels).

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