Respected Sir(2): Magic Target for Diabetes

Overview

Journal Cellscience

Specialty Cell Biology

Date 2011 Sep 28

PMID 20577646

Citations 3

Authors

Pratibha V Nerurkar

Vivek R Nerurkar

Affiliations

Soon will be listed here.

Abstract

The endless quest for the 'fountain of youth' has led to the discovery of a family of molecules known as sirtuins in humans, or silent mating type information regulator 2 (Sir2) in yeast, which are associated with longevity in yeast, nematodes, drosophila and rodents. Although sirtuins have yet to be proven to delay aging and promote longevity in humans, they promise 'healthy aging', an ideal of modern society. This review emphasizes the role of various sirtuins in maintaining glucose homeostasis, the therapeutic potential of sirtuin modulators in the prevention and treatment of diabetes, and the emerging associations of SIRT genetic polymorphisms with human longevity.

Citing Articles

Role of Sirtuins in Linking Metabolic Syndrome with Depression.

Song J, Kim J Front Cell Neurosci. 2016; 10:86.

PMID: 27065808 PMC: 4814520. DOI: 10.3389/fncel.2016.00086.

Metabolism of skin-absorbed resveratrol into its glucuronized form in mouse skin.

Murakami I, Chaleckis R, Pluskal T, Ito K, Hori K, Ebe M PLoS One. 2014; 9(12):e115359.

PMID: 25506824 PMC: 4266648. DOI: 10.1371/journal.pone.0115359.

Can Sir(2) regulate cancer?.

Nerurkar P, Nerurkar V Cellscience. 2011; 4(4):50-56.

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