AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator
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SIRT1 is a protein deacetylase that regulates cellular responses to a variety of stresses. In a recent issue of Molecular Cell, Kim et al. (2007) report the identification of a cellular protein, AROS, that activates the SIRT1-mediated deacetylation of p53.
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