Gr-1+CD11b+ Myeloid-derived Suppressor Cells: Formidable Partners in Tumor Metastasis

Overview

Journal J Bone Miner Res

Publisher Oxford University Press

Date 2010 Jun 24

PMID 20572008

Citations 36

Authors

Li Yang

Claire M Edwards

Gregory R Mundy

Affiliations

Soon will be listed here.

Abstract

The growth and metastasis of solid tumors not only depends on their ability to escape from immune surveillance but also hinges on their ability to invade the vasculature system as well as to induce the formation of new blood vessels. Gr-1(+)CD11b(+) myeloid-derived suppressor cells (MDSCs), overproduced in tumor-bearing hosts, contribute significantly to all these aspects. They also have a potential role in the osteolysis associated with bone metastases. They are formidable partners in tumor metastasis.

Citing Articles

Utilization of Cannabidiol in Post-Organ-Transplant Care.

Koyama S, Etkins J, Jun J, Miller M, So G, Gisch D Int J Mol Sci. 2025; 26(2).

PMID: 39859413 PMC: 11765766. DOI: 10.3390/ijms26020699.

Leveraging the synergy between anti-angiogenic therapy and immune checkpoint inhibitors to treat digestive system cancers.

Xu Q, Shao D Front Immunol. 2024; 15:1487610.

PMID: 39691707 PMC: 11649667. DOI: 10.3389/fimmu.2024.1487610.

TUMOR-INFILTRATING NOCICEPTOR NEURONS PROMOTE IMMUNOSUPPRESSION.

Restaino A, Ahmadi M, Nikpoor A, Walz A, Balood M, Eichwald T bioRxiv. 2024; .

PMID: 39253487 PMC: 11382997. DOI: 10.1101/2024.08.23.609450.

Degradation-resistant implanted biomaterials establish an immunosuppressive microenvironment that induces T cell exhaustion by recruiting myeloid cells.

Fan Q, Dai H, Bai J, Xu J, Ma Q, Fei Z Fundam Res. 2024; 2(4):648-658.

PMID: 38933993 PMC: 11197691. DOI: 10.1016/j.fmre.2021.10.007.

High-Frequency Nanosecond Bleomycin Electrochemotherapy and its Effects on Changes in the Immune System and Survival.

Baleviciute A, Radzeviciute E, Zelvys A, Malysko-Ptasinske V, Novickij J, Zinkeviciene A Cancers (Basel). 2022; 14(24).

PMID: 36551739 PMC: 9776811. DOI: 10.3390/cancers14246254.

References

Trapani J . The dual adverse effects of TGF-beta secretion on tumor progression. Cancer Cell. 2005; 8(5):349-50. DOI: 10.1016/j.ccr.2005.10.018. View

Bristow R, Hill R . Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer. 2008; 8(3):180-92. DOI: 10.1038/nrc2344. View

Ghiringhelli F, Menard C, Terme M, Flament C, Taieb J, Chaput N . CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med. 2005; 202(8):1075-85. PMC: 2213209. DOI: 10.1084/jem.20051511. View

Radl J, De Glopper E, SCHUIT H, Zurcher C . Idiopathic paraproteinemia. II. Transplantation of the paraprotein-producing clone from old to young C57BL/KaLwRij mice. J Immunol. 1979; 122(2):609-13. View

Nagaraj S, Gupta K, Pisarev V, Kinarsky L, Sherman S, Kang L . Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat Med. 2007; 13(7):828-35. PMC: 2135607. DOI: 10.1038/nm1609. View

Du R, Lu K, Petritsch C, Liu P, Ganss R, Passegue E . HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008; 13(3):206-20. PMC: 2643426. DOI: 10.1016/j.ccr.2008.01.034. View

Bhowmick N, Neilson E, Moses H . Stromal fibroblasts in cancer initiation and progression. Nature. 2004; 432(7015):332-7. PMC: 3050735. DOI: 10.1038/nature03096. View

Lu S, Herrington H, Reh D, Weber S, Bornstein S, Wang D . Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev. 2006; 20(10):1331-42. PMC: 1472907. DOI: 10.1101/gad.1413306. View

Luo J, Tan W, Ricono J, Korchynskyi O, Zhang M, Gonias S . Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007; 446(7136):690-4. DOI: 10.1038/nature05656. View

10.

Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom T . IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 2007; 448(7152):484-487. PMC: 3805028. DOI: 10.1038/nature05970. View

11.

Maggio-Price L, Treuting P, Zeng W, Tsang M, Bielefeldt-Ohmann H, Iritani B . Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice. Cancer Res. 2006; 66(2):828-38. PMC: 5367923. DOI: 10.1158/0008-5472.CAN-05-2448. View

12.

Ferrara N, Hillan K, Gerber H, Novotny W . Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov. 2004; 3(5):391-400. DOI: 10.1038/nrd1381. View

13.

Padua D, Zhang X, Wang Q, Nadal C, Gerald W, Gomis R . TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell. 2008; 133(1):66-77. PMC: 2390892. DOI: 10.1016/j.cell.2008.01.046. View

14.

Balkwill F, Coussens L . Cancer: an inflammatory link. Nature. 2004; 431(7007):405-6. DOI: 10.1038/431405a. View

15.

Nam J, Terabe M, Kang M, Chae H, Voong N, Yang Y . Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res. 2008; 68(10):3915-23. PMC: 2586596. DOI: 10.1158/0008-5472.CAN-08-0206. View

16.

Wahl S, Wen J, Moutsopoulos N . TGF-beta: a mobile purveyor of immune privilege. Immunol Rev. 2006; 213:213-27. DOI: 10.1111/j.1600-065X.2006.00437.x. View

17.

Movahedi K, Guilliams M, Van den Bossche J, Van den Bergh R, Gysemans C, Beschin A . Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood. 2008; 111(8):4233-44. DOI: 10.1182/blood-2007-07-099226. View

18.

Yang L, Huang J, Ren X, Gorska A, Chytil A, Aakre M . Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell. 2008; 13(1):23-35. PMC: 2245859. DOI: 10.1016/j.ccr.2007.12.004. View

19.

Shojaei F, Wu X, Malik A, Zhong C, Baldwin M, Schanz S . Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol. 2007; 25(8):911-20. DOI: 10.1038/nbt1323. View

20.

Marx J . Cancer immunology. Cancer's bulwark against immune attack: MDS cells. Science. 2008; 319(5860):154-6. DOI: 10.1126/science.319.5860.154. View