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Distinct Biological Network Properties Between the Targets of Natural Products and Disease Genes

Overview
Journal J Am Chem Soc
Publisher American Chemical Society
Specialty Chemistry
Date 2010 Jun 23
PMID 20565092
Citations 23
Authors
Vlado Dancik
Kathleen Petri Seiler
Damian W Young
Stuart L Schreiber
Paul A Clemons
Affiliations
Soon will be listed here.
Abstract

We show that natural products target proteins with a high number of protein-protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future.

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