Development of the Hippocampal Cognitive Map in Preweanling Rats

Overview

Journal Science

Specialty Science

Date 2010 Jun 19

PMID 20558720

Citations 250

Authors

Tom J Wills

Francesca Cacucci

Neil Burgess

John OKeefe

Affiliations

Soon will be listed here.

Abstract

Orienting in large-scale space depends on the interaction of environmental experience and preconfigured, possibly innate, constructs. Place, head-direction, and grid cells in the hippocampal formation provide allocentric representations of space. Here we show how these cognitive representations emerge and develop as rat pups first begin to explore their environment. Directional, locational, and rhythmic organization of firing are present during initial exploration, including adultlike directional firing. The stability and precision of place cell firing continue to develop throughout juvenility. Stable grid cell firing appears later but matures rapidly to adult levels. Our results demonstrate the presence of three neuronal representations of space before extensive experience and show how they develop with age.

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