How Do Cdc7 and Cyclin-dependent Kinases Trigger the Initiation of Chromosome Replication in Eukaryotic Cells?

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2010 Jun 17

PMID 20551170

Citations 213

Authors

Karim Labib

Affiliations

Soon will be listed here.

Abstract

Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during the initiation of chromosome replication, and a key feature of this process is the activation of the replicative DNA helicase in situ at each origin of DNA replication. A series of recent studies has shed new light on the targets of Cdc7 and CDK, indicating that chromosome replication probably initiates by a fundamentally similar mechanism in all eukaryotes.

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