[Principles of Skin Pigmentation. Biochemistry and Regulation of Melanogenesis]

Overview

Journal Hautarzt

Specialty Dermatology

Date 2010 Jun 16

PMID 20549482

Citations 4

Authors

M Brenner

C Berking

Affiliations

Soon will be listed here.

Abstract

Skin pigmentation is highly determined by genetic factors and so far more than 150 genes have been identified that affect skin color either directly or indirectly. The production of eu- and pheomelanin in melanosomes results from the complex interaction between melanogenic regulators in melanocytes and factors derived from keratinocytes and fibroblasts. Besides genetic determination, pigmentation depends on environmental and endocrine factors that modulate the amount, type and distribution of melanins in the skin. Understanding the intrinsic mechanisms of melanogenesis is the basis for modifications of skin pigmentation which are of great interest pharmaceutically and cosmeceutically.

Citing Articles

Antioxidant Compounds, Kirenol and Methyl ent-16α, 17-dihydroxy-kauran-19-oate Bioactivity-Guided Isolated from Attenuates MITF-Mediated Melanogenesis via Inhibition of Intracellular ROS Production.

Shim S, Lee Y, Lee M Molecules. 2021; 26(7).

PMID: 33808322 PMC: 8036764. DOI: 10.3390/molecules26071940.

-Hydroxybenzoic Acid β-d-Glucosyl Ester and Cimidahurinine with Antimelanogenesis and Antioxidant Effects from via Bioactivity-Guided Fractionation.

Shim S, Lee Y, Song H, Lee M Antioxidants (Basel). 2020; 9(3).

PMID: 32245245 PMC: 7139487. DOI: 10.3390/antiox9030258.

Role of alpha-melanocyte stimulating hormone (α-MSH) in modulating the molecular mechanism adopted by melanocytes of Bos indicus under UVR stress.

Choudhary R, Sharma A, Kumar S, Upadhyay R, Singh S, Mohanty A Mol Cell Biochem. 2019; 465(1-2):141-153.

PMID: 31823188 DOI: 10.1007/s11010-019-03674-w.

Antioxidative and Antimelanogenesis Effect of Methanol Extract.

Park S, Yi Y, Kim M, Cho J Evid Based Complement Alternat Med. 2019; 2019:5091534.

PMID: 31186660 PMC: 6521336. DOI: 10.1155/2019/5091534.

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