[The Role of Ultraviolet Irradiation in Malignant Melanoma]

Overview

Journal Hautarzt

Specialty Dermatology

Date 2005 Jun 22

PMID 15968560

Citations 4

Authors

C Berking

Affiliations

Soon will be listed here.

Abstract

The incidence of melanoma has been rising during the past 40 years and may be the result of lifestyle changes that have led to an increased sun exposure in fair-skinned people. Ultraviolet radiation (UVR) is believed to be the main causative factor in melanoma development with an acute intermittent exposure being more relevant than a chronic cumulative one. While UVB (280-320 nm) can directly cause DNA damage (UVB fingerprint mutations) in the cells of the epidermis, UVA (320-400 nm) induces damage indirectly by the formation of reactive oxygen species. Since UV-associated mutations are rare in melanoma, it is speculated that UVR supports melanoma development by indirect effects, e.g. immunosuppression or stimulation of growth factors in the skin. Taken together, animal models and epidemiological data suggest a UVA-associated pathogenesis of melanoma that puts into question the effectiveness of sunscreens in melanoma prevention.

Citing Articles

Psychosocial Care Needs of Melanoma Survivors: Are They Being Met?.

Fischbeck S, Imruck B, Blettner M, Weyer V, Binder H, Zeissig S PLoS One. 2015; 10(8):e0132754.

PMID: 26296089 PMC: 4546620. DOI: 10.1371/journal.pone.0132754.

[Principles of skin pigmentation. Biochemistry and regulation of melanogenesis].

Brenner M, Berking C Hautarzt. 2010; 61(7):554-60.

PMID: 20549482 DOI: 10.1007/s00105-009-1913-z.

UV-induced skin cancer at workplace and evidence-based prevention.

Kutting B, Drexler H Int Arch Occup Environ Health. 2010; 83(8):843-54.

PMID: 20414668 DOI: 10.1007/s00420-010-0532-4.

[Photocarcinogenesis. Molecular mechanisms and preventive strategies].

Berking C Hautarzt. 2007; 58(5):398-405.

PMID: 17429584 DOI: 10.1007/s00105-007-1319-8.

References

van Schanke A, Jongsma M, Bisschop R, van Venrooij G, Rebel H, de Gruijl F . Single UVB overexposure stimulates melanocyte proliferation in murine skin, in contrast to fractionated or UVA-1 exposure. J Invest Dermatol. 2005; 124(1):241-7. DOI: 10.1111/j.0022-202X.2004.23551.x. View

Brenner M, Degitz K, Besch R, Berking C . Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation. Br J Dermatol. 2005; 153(4):733-9. DOI: 10.1111/j.1365-2133.2005.06780.x. View

Burren R, Scaletta C, Frenk E, Panizzon R, Applegate L . Sunlight and carcinogenesis: expression of p53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiations. Int J Cancer. 1998; 76(2):201-6. DOI: 10.1002/(sici)1097-0215(19980413)76:2<201::aid-ijc6>3.0.co;2-0. View

Polsky D, Cordon-Cardo C . Oncogenes in melanoma. Oncogene. 2003; 22(20):3087-91. DOI: 10.1038/sj.onc.1206449. View

Jhappan C, Noonan F, Merlino G . Ultraviolet radiation and cutaneous malignant melanoma. Oncogene. 2003; 22(20):3099-112. DOI: 10.1038/sj.onc.1206450. View

Berking C, Takemoto R, Satyamoorthy K, Shirakawa T, Eskandarpour M, Hansson J . Induction of melanoma phenotypes in human skin by growth factors and ultraviolet B. Cancer Res. 2004; 64(3):807-11. DOI: 10.1158/0008-5472.can-03-3438. View

Berking C, Takemoto R, Binder R, Hartman S, Ruiter D, Gallagher P . Photocarcinogenesis in human adult skin grafts. Carcinogenesis. 2002; 23(1):181-7. DOI: 10.1093/carcin/23.1.181. View

Wang S, Setlow R, Berwick M, Polsky D, Marghoob A, Kopf A . Ultraviolet A and melanoma: a review. J Am Acad Dermatol. 2001; 44(5):837-46. DOI: 10.1067/mjd.2001.114594. View

Chudnovsky Y, Khavari P, Adams A . Melanoma genetics and the development of rational therapeutics. J Clin Invest. 2005; 115(4):813-24. PMC: 1070435. DOI: 10.1172/JCI24808. View

10.

Swerdlow A, Weinstock M . Do tanning lamps cause melanoma? An epidemiologic assessment. J Am Acad Dermatol. 1998; 38(1):89-98. DOI: 10.1016/s0190-9622(98)70544-4. View

11.

Garland C, Garland F, Gorham E . Epidemiologic evidence for different roles of ultraviolet A and B radiation in melanoma mortality rates. Ann Epidemiol. 2003; 13(6):395-404. DOI: 10.1016/s1047-2797(02)00461-1. View

12.

Bachelor M, Bowden G . UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin Cancer Biol. 2004; 14(2):131-8. DOI: 10.1016/j.semcancer.2003.09.017. View

13.

Agar N, Halliday G, Barnetson R, Ananthaswamy H, Wheeler M, Jones A . The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis. Proc Natl Acad Sci U S A. 2004; 101(14):4954-9. PMC: 387355. DOI: 10.1073/pnas.0401141101. View

14.

Gilchrest B, Eller M, Geller A, Yaar M . The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med. 1999; 340(17):1341-8. DOI: 10.1056/NEJM199904293401707. View

15.

Berwick M, Armstrong B, Ben-Porat L, Fine J, Kricker A, Eberle C . Sun exposure and mortality from melanoma. J Natl Cancer Inst. 2005; 97(3):195-9. DOI: 10.1093/jnci/dji019. View

16.

De Fabo E, Noonan F, Fears T, Merlino G . Ultraviolet B but not ultraviolet A radiation initiates melanoma. Cancer Res. 2004; 64(18):6372-6. DOI: 10.1158/0008-5472.CAN-04-1454. View