Pathogen-specific Regulatory T Cells Delay the Arrival of Effector T Cells in the Lung During Early Tuberculosis

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2010 Jun 16

PMID 20547826

Citations 176

Authors

Shahin Shafiani

Gladys Tucker-Heard

Ai Kariyone

Kiyoshi Takatsu

Kevin B Urdahl

Affiliations

Soon will be listed here.

Abstract

The ability of the adaptive immune system to restrict Mycobacterium tuberculosis (Mtb) is impeded by activated Foxp3(+) regulatory T (T reg) cells. The importance of pathogen-specific T reg cells in this process has not been addressed. We show that T reg cell expansion after aerosol Mtb infection does not occur until Mtb is transported to the pulmonary lymph node (pLN), and Mtb-specific T reg cells have an increased propensity to proliferate. Even small numbers of Mtb-specific T reg cells are capable of delaying the priming of effector CD4(+) and CD8(+) T cells in the pLN and their subsequent accumulation in the lung, the primary site of infection. This delay likely prolongs the initial phase of bacterial expansion and explains the higher bacterial burden observed in these mice. Thus, T reg cells recognizing Mtb-derived antigens specifically and potently restrict protective immune responses during tuberculosis.

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